A CHOLINERGIC MECHANISM OF INHIBITORY SYNAPTIC TRANSMISSION IN A MOLLUSCAN NERVOUS SYSTEM

A CHOLINERGIC MECHANISM OF INHIBITORY SYNAPTIC TRANSMISSION IN A MOLLUSCAN NERVOUS SYSTEM CHOLINERGIC INHIBITORY SYNAPSES Furthermore, the synapses activating the Renshaw cell are cholinergic (25, 26). In invertebrates, cholinergic transmission was postulated, mainly based on biochemical arguments, for neuromuscular junctions of longitudinal muscles in Hirudo medicinalis (5), neuromuscular junctions of the retractor muscles of the holothurian Stichopus regalis (3) and cardio-inhibitory synapses of the clam Venus mercenaria (45,60). We have previously reported (56) that in the ganglion cells of HeZLr pomatia acetylcholine applied in weak concentrations produces a clear modification of their excitatory state, but whereas some cells were excited other cells were strikingly inhibited. It was also shown that this inhibitory effect could be reversed by changing the polarization level of the cell membrane. This study of acetylcholine action was further extended to the ganglion cells of Aplysia depilans which have a simpler afferent synaptic system than that of snail neurons, therefore giving greater reliability in the interpretation of the experimental results. The investigations presented in this paper were designed to test a possible role of acetylcholine in inhibitory synaptic transmission in Aplysia. Evidence was obtained suggesting that acetylcholine is the inhibitory synaptic transmitter in the Aplysia central nervous system. A preliminary report of this work has been published http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

A CHOLINERGIC MECHANISM OF INHIBITORY SYNAPTIC TRANSMISSION IN A MOLLUSCAN NERVOUS SYSTEM

Loading next page...
 
/lp/the-american-physiological-society/a-cholinergic-mechanism-of-inhibitory-synaptic-transmission-in-a-jwazfC11gM
Publisher
The American Physiological Society
Copyright
Copyright © 1962 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
See Article on Publisher Site

Abstract

CHOLINERGIC INHIBITORY SYNAPSES Furthermore, the synapses activating the Renshaw cell are cholinergic (25, 26). In invertebrates, cholinergic transmission was postulated, mainly based on biochemical arguments, for neuromuscular junctions of longitudinal muscles in Hirudo medicinalis (5), neuromuscular junctions of the retractor muscles of the holothurian Stichopus regalis (3) and cardio-inhibitory synapses of the clam Venus mercenaria (45,60). We have previously reported (56) that in the ganglion cells of HeZLr pomatia acetylcholine applied in weak concentrations produces a clear modification of their excitatory state, but whereas some cells were excited other cells were strikingly inhibited. It was also shown that this inhibitory effect could be reversed by changing the polarization level of the cell membrane. This study of acetylcholine action was further extended to the ganglion cells of Aplysia depilans which have a simpler afferent synaptic system than that of snail neurons, therefore giving greater reliability in the interpretation of the experimental results. The investigations presented in this paper were designed to test a possible role of acetylcholine in inhibitory synaptic transmission in Aplysia. Evidence was obtained suggesting that acetylcholine is the inhibitory synaptic transmitter in the Aplysia central nervous system. A preliminary report of this work has been published

Journal

Journal of NeurophysiologyThe American Physiological Society

Published: Mar 1, 1962

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off