CHOLINERGIC INHIBITORY SYNAPSES Furthermore, the synapses activating the Renshaw cell are cholinergic (25, 26). In invertebrates, cholinergic transmission was postulated, mainly based on biochemical arguments, for neuromuscular junctions of longitudinal muscles in Hirudo medicinalis (5), neuromuscular junctions of the retractor muscles of the holothurian Stichopus regalis (3) and cardio-inhibitory synapses of the clam Venus mercenaria (45,60). We have previously reported (56) that in the ganglion cells of HeZLr pomatia acetylcholine applied in weak concentrations produces a clear modification of their excitatory state, but whereas some cells were excited other cells were strikingly inhibited. It was also shown that this inhibitory effect could be reversed by changing the polarization level of the cell membrane. This study of acetylcholine action was further extended to the ganglion cells of Aplysia depilans which have a simpler afferent synaptic system than that of snail neurons, therefore giving greater reliability in the interpretation of the experimental results. The investigations presented in this paper were designed to test a possible role of acetylcholine in inhibitory synaptic transmission in Aplysia. Evidence was obtained suggesting that acetylcholine is the inhibitory synaptic transmitter in the Aplysia central nervous system. A preliminary report of this work has been published
Journal of Neurophysiology – The American Physiological Society
Published: Mar 1, 1962
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