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Variable selection and nonlinear effect discovery in partially linear mixture cure rate models

Variable selection and nonlinear effect discovery in partially linear mixture cure rate models Survival data with long-term survivors are common in clinical investigations. Such data are often analyzed with mixture cure rate models. Existing model selection procedures do not readily discriminate nonlinear effects from linear ones. Here, we propose a procedure for accommodating nonlinear effects and for determining the cure rate model composition. The procedure is based on the Least Absolute Shrinkage and Selection Operators (LASSO). Specifically, by partitioning each variable into linear and nonlinear components, we use LASSO to select linear and nonlinear components. Operationally, we model the nonlinear components by cubic B-splines. The procedure adds to the existing variable selection methods an ability to discover hidden nonlinear effects in a cure rate model setting. To implement, we ascertain the maximum likelihood estimates by using an Expectation Maximization (EM) algorithm. We conduct an extensive simulation study to assess the operating characteristics of the selection procedure. We illustrate the use of the method by analyzing data from a real clinical study. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biostatistics & Epidemiology Taylor & Francis

Variable selection and nonlinear effect discovery in partially linear mixture cure rate models

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Variable selection and nonlinear effect discovery in partially linear mixture cure rate models

Abstract

Survival data with long-term survivors are common in clinical investigations. Such data are often analyzed with mixture cure rate models. Existing model selection procedures do not readily discriminate nonlinear effects from linear ones. Here, we propose a procedure for accommodating nonlinear effects and for determining the cure rate model composition. The procedure is based on the Least Absolute Shrinkage and Selection Operators (LASSO). Specifically, by partitioning each variable into...
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Publisher
Taylor & Francis
Copyright
© 2019 International Biometric Society – Chinese Region
ISSN
2470-9379
eISSN
2470-9360
DOI
10.1080/24709360.2019.1663665
Publisher site
See Article on Publisher Site

Abstract

Survival data with long-term survivors are common in clinical investigations. Such data are often analyzed with mixture cure rate models. Existing model selection procedures do not readily discriminate nonlinear effects from linear ones. Here, we propose a procedure for accommodating nonlinear effects and for determining the cure rate model composition. The procedure is based on the Least Absolute Shrinkage and Selection Operators (LASSO). Specifically, by partitioning each variable into linear and nonlinear components, we use LASSO to select linear and nonlinear components. Operationally, we model the nonlinear components by cubic B-splines. The procedure adds to the existing variable selection methods an ability to discover hidden nonlinear effects in a cure rate model setting. To implement, we ascertain the maximum likelihood estimates by using an Expectation Maximization (EM) algorithm. We conduct an extensive simulation study to assess the operating characteristics of the selection procedure. We illustrate the use of the method by analyzing data from a real clinical study.

Journal

Biostatistics & Epidemiology – Taylor & Francis

Published: Jan 1, 2019

Keywords: Mixture cure rate models; LASSO; cubic B-splines; variable selection

References

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