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Exact inference for the Youden index to discriminate individuals using two-parameter exponentially distributed pooled samples

Exact inference for the Youden index to discriminate individuals using two-parameter... It has become increasingly common in epidemiological studies to pool specimens across subjects as a useful cot-cutting technique to achieve accurate quantification of biomarkers and certain environmental chemicals. The data collected from these pooled samples can then be utilized to estimate the Youden Index, which measures biomarker's effectiveness and aids in the selection of an optimal threshold value, as a summary measure of the Receiver Operating Characteristic curve. The aim of this paper is to make use of generalized approach to estimate and testing of the Youden index. This goal is accomplished by the comparison of classical and generalized procedures for the Youden Index with the aid of pooled samples from the shifted-exponentially distributed biomarkers for the low-risk and high-risk patients. These are juxtaposed using confidence intervals, p-values, power of the test, size of the test, and coverage probability with a wide-ranging simulation study featuring a selection of various scenarios. In order to demonstrate the advantages of the proposed generalized procedures over its classical counterpart, an illustrative example is discussed using the Duchenne Muscular Dystrophy data available at http://biostat.mc.vanderbilt.edu/wiki/Main/DataSets or http://lib.stat.cmu.edu/datasets/. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biostatistics & Epidemiology Taylor & Francis

Exact inference for the Youden index to discriminate individuals using two-parameter exponentially distributed pooled samples

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Exact inference for the Youden index to discriminate individuals using two-parameter exponentially distributed pooled samples

Abstract

It has become increasingly common in epidemiological studies to pool specimens across subjects as a useful cot-cutting technique to achieve accurate quantification of biomarkers and certain environmental chemicals. The data collected from these pooled samples can then be utilized to estimate the Youden Index, which measures biomarker's effectiveness and aids in the selection of an optimal threshold value, as a summary measure of the Receiver Operating Characteristic curve. The aim of...
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Publisher
Taylor & Francis
Copyright
© 2019 International Biometric Society – Chinese Region
ISSN
2470-9379
eISSN
2470-9360
DOI
10.1080/24709360.2019.1587264
Publisher site
See Article on Publisher Site

Abstract

It has become increasingly common in epidemiological studies to pool specimens across subjects as a useful cot-cutting technique to achieve accurate quantification of biomarkers and certain environmental chemicals. The data collected from these pooled samples can then be utilized to estimate the Youden Index, which measures biomarker's effectiveness and aids in the selection of an optimal threshold value, as a summary measure of the Receiver Operating Characteristic curve. The aim of this paper is to make use of generalized approach to estimate and testing of the Youden index. This goal is accomplished by the comparison of classical and generalized procedures for the Youden Index with the aid of pooled samples from the shifted-exponentially distributed biomarkers for the low-risk and high-risk patients. These are juxtaposed using confidence intervals, p-values, power of the test, size of the test, and coverage probability with a wide-ranging simulation study featuring a selection of various scenarios. In order to demonstrate the advantages of the proposed generalized procedures over its classical counterpart, an illustrative example is discussed using the Duchenne Muscular Dystrophy data available at http://biostat.mc.vanderbilt.edu/wiki/Main/DataSets or http://lib.stat.cmu.edu/datasets/.

Journal

Biostatistics & Epidemiology – Taylor & Francis

Published: Jan 1, 2019

Keywords: Generalized variable method; power of the test; size of the test; shifted-exponential distribution; Youden index; 62F03; 62F10

References

  • Of bombers, radiologists, and cardiologists: time to ROC
  • The ROC curve and the area under it as performance measures
  • The use of receiver operating characteristic curves in biomedical informatics
  • Receiver operating characteristic curve analysis of beach water quality indicator variables
  • Estimation of the Youden index and its associated cut-off point
  • The interpretation of diagnostic tests
  • Principles and practical application of the receiver operating characteristic analysis for diagnostic tests
  • Most reliable indices in differentiation between thalassemial trait and iron deficiency anemia
  • Youden index and the optimal threshold for markers with mass at zero
  • Generalized confidence intervals
  • Generalized p-values in significance testing of hypotheses in the presence of nuisance parameters
  • Theoretical comparison of bootstrap confidence intervals
  • Generalized point estimation with application to small response estimation
  • Inference for the reliability function based on progressively type II censored data from the Pareto model: the generalized variable approach
  • Inference for the Burr XII reliability under progressive censoring with random removals
  • Inferences on functions of Pareto parameters with applications to income inequality
  • Generalized inferences for the expected winning bids
  • Generalized inference of for Pareto distribution
  • Generalized variable method inference for the location parameter of the general half-normal distribution
  • Inferences on the common mean of several normal populations based on the generalized variable method
  • A new approach for interval estimation and hypothesis testing of a certain intraclass correlation coefficient: the generalized variable method
  • Optimal cut-point and its corresponding Youden index to discriminate individuals using pooled blood samples