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ENHANCEMENT OF DNA HYBRIDIZATION KINETICS IN MICROARRAYS BY CONVECTIVE TRANSPORT

ENHANCEMENT OF DNA HYBRIDIZATION KINETICS IN MICROARRAYS BY CONVECTIVE TRANSPORT We use the finite element method (Comsol Multiphysics software) to study the kinetics of DNA hybridization and the potential limitation of the reaction rate caused by diffusion effects. The value of the parameters influencing the kinetics can sometimes span several orders of magnitude. Therefore, a wide range of values was used in order to cover the conditions seen in DNA microarrays. In the cases where hybridization is diffusion limited, a convective transport is added to successfully overcome this limitation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemical Engineering Communications Taylor & Francis

ENHANCEMENT OF DNA HYBRIDIZATION KINETICS IN MICROARRAYS BY CONVECTIVE TRANSPORT

Chemical Engineering Communications , Volume 195 (2): 20 – Nov 21, 2007
20 pages

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References (25)

Publisher
Taylor & Francis
Copyright
Copyright Taylor & Francis Group, LLC
ISSN
1563-5201
eISSN
0098-6445
DOI
10.1080/00986440701569283
Publisher site
See Article on Publisher Site

Abstract

We use the finite element method (Comsol Multiphysics software) to study the kinetics of DNA hybridization and the potential limitation of the reaction rate caused by diffusion effects. The value of the parameters influencing the kinetics can sometimes span several orders of magnitude. Therefore, a wide range of values was used in order to cover the conditions seen in DNA microarrays. In the cases where hybridization is diffusion limited, a convective transport is added to successfully overcome this limitation.

Journal

Chemical Engineering CommunicationsTaylor & Francis

Published: Nov 21, 2007

Keywords: DNA hybridization; Diffusion; Diffusion limitation; Hybridization kinetics

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