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A response adaptive design for ordinal categorical responses weighing the cumulative odds ratios

A response adaptive design for ordinal categorical responses weighing the cumulative odds ratios Weighing the cumulative odds ratios suitably, a two treatment response adaptive design for phase III clinical trial is proposed for ordinal categorical responses. Properties of the proposed design are investigated theoretically as well as empirically. Applicability of the design is further verified using a data pertaining to a real clinical trial with trauma patients, where the responses are observed in an ordinal categorical scale. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biostatistics & Epidemiology Taylor & Francis

A response adaptive design for ordinal categorical responses weighing the cumulative odds ratios

A response adaptive design for ordinal categorical responses weighing the cumulative odds ratios

Abstract

Weighing the cumulative odds ratios suitably, a two treatment response adaptive design for phase III clinical trial is proposed for ordinal categorical responses. Properties of the proposed design are investigated theoretically as well as empirically. Applicability of the design is further verified using a data pertaining to a real clinical trial with trauma patients, where the responses are observed in an ordinal categorical scale.
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Publisher
Taylor & Francis
Copyright
© 2019 International Biometric Society – Chinese Region
ISSN
2470-9379
eISSN
2470-9360
DOI
10.1080/24709360.2019.1660111
Publisher site
See Article on Publisher Site

Abstract

Weighing the cumulative odds ratios suitably, a two treatment response adaptive design for phase III clinical trial is proposed for ordinal categorical responses. Properties of the proposed design are investigated theoretically as well as empirically. Applicability of the design is further verified using a data pertaining to a real clinical trial with trauma patients, where the responses are observed in an ordinal categorical scale.

Journal

Biostatistics & EpidemiologyTaylor & Francis

Published: Jan 1, 2019

Keywords: Response adaptive design; ordinal categorical responses; cumulative odds ratio

References