Some novel 3-[(alkyl/arylthio)(aryl)methyl]-1H-indoles (4a–h) are prepared via a one-pot, three-component, and domino reaction of indoles, aromatic aldehydes, and various (hetero) aromatic thiols in the presence of zirconium oxy dichloride octahydrate as an efficient green Lewis acid catalyst. Mild reaction conditions, simple reaction procedure, good yields of products, inexpensive and eco-friendly catalyst usage, lack of by-products formation, such as dithioacetals from aromatic aldehydes, as well as bis(indolyl)methanes, are the highlighted points of the presented protocol.
Research on Chemical Intermediates – Springer Journals
Published: Mar 23, 2016
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