Zeolites as model solids for investigations on the role of iron at the solid-liquid interface in particulate toxicity

Zeolites as model solids for investigations on the role of iron at the solid-liquid interface in... In order to investigate the molecular mechanism whereby iron in asbestos and in other iron containing fibres plays a crucial role in fibre induced carcinogenicity, two Fe2+-exchanged zeolites (Y and H-ZSM-5) have been prepared and used as model solids. Fe-Y was active both in free radical generation via hydrogen abstraction and in single strand DNA damage, but lost both these properties when oxidized by hydrogen peroxide. Fe-ZSM-5, on the other hand, was nearly inactive. Iron chelators and reductants (ascorbate, citrate and EDTA) enhance the activity in DNA single strand breaks. Moreover, they reactivate oxidized Fe-Y and activate Fe-ZSM-5. Iron is mobilized and Fe3+ is partially reduced to Fe2+. The most pronounced effect was found when citrate was present together with ascorbate. H-abstraction turns out to be a rather general reaction, occurring also with peptides as target molecules. In this case EPR spectra show that more than one type of radical moiety is generated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Zeolites as model solids for investigations on the role of iron at the solid-liquid interface in particulate toxicity

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Publisher
Springer Netherlands
Copyright
Copyright © 1999 by Springer
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1163/156856799X00400
Publisher site
See Article on Publisher Site

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