J Cancer Res Clin Oncol (2017) 143:1679–1686 DOI 10.1007/s00432-017-2414-6 ORIGINAL ARTICLE – CANCER RESEARCH 1 1 1 1 1 Ouchen Wang · Zhouci Zheng · Qingxuan Wang · Yixiang Jin · Wenxu Jin · 1 1 1 Yinghao Wang · Endong Chen · Xiaohua Zhang Received: 3 March 2017 / Accepted: 30 March 2017 / Published online: 19 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract the validated cohort while 91.4% for the TCGA cohort to Purpose Thyroid cancer is the most common endocrine classify PTC tumors and normal tissues. ZCCHC12 over- malignancy worldwide. The molecular mechanisms under- expression correlated with lymph node metastasis in both lying thyroid tumorigenesis remain unclear. Some studies cohorts (P < 0.05). In in vitro experiments, ZCCHC12 suggested that the ZCCHC12 gene correlates with certain downregulation significantly inhibited the colony forma - diseases. However, the function of ZCCHC12 in thyroid tion, migration, and invasion of PTC cells. cancer has yet to be determined. This study investigated Conclusion Our study indicated that ZCCHC12 gene has the role of the ZCCHC12 gene in papillary thyroid cancer important biological functions and acts as a metastasis- (PTC). related oncogene in PTC. Methods We conducted a comprehensive analysis of
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Apr 19, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera