ZCCHC12, a novel oncogene in papillary thyroid cancer

ZCCHC12, a novel oncogene in papillary thyroid cancer J Cancer Res Clin Oncol (2017) 143:1679–1686 DOI 10.1007/s00432-017-2414-6 ORIGINAL ARTICLE – CANCER RESEARCH 1 1 1 1 1 Ouchen Wang · Zhouci Zheng · Qingxuan Wang · Yixiang Jin · Wenxu Jin · 1 1 1 Yinghao Wang · Endong Chen · Xiaohua Zhang Received: 3 March 2017 / Accepted: 30 March 2017 / Published online: 19 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract the validated cohort while 91.4% for the TCGA cohort to Purpose Thyroid cancer is the most common endocrine classify PTC tumors and normal tissues. ZCCHC12 over- malignancy worldwide. The molecular mechanisms under- expression correlated with lymph node metastasis in both lying thyroid tumorigenesis remain unclear. Some studies cohorts (P < 0.05). In in vitro experiments, ZCCHC12 suggested that the ZCCHC12 gene correlates with certain downregulation significantly inhibited the colony forma - diseases. However, the function of ZCCHC12 in thyroid tion, migration, and invasion of PTC cells. cancer has yet to be determined. This study investigated Conclusion Our study indicated that ZCCHC12 gene has the role of the ZCCHC12 gene in papillary thyroid cancer important biological functions and acts as a metastasis- (PTC). related oncogene in PTC. Methods We conducted a comprehensive analysis of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Research and Clinical Oncology Springer Journals

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
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