Cardiovasc Intervent Radiol (2017) 40:1383–1391 DOI 10.1007/s00270-017-1648-7 CLINICAL INVESTIGATION INTERVENTIONAL ONCOLOGY Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma 1 1 2 1 • • • • Lauren S. Chan Daniel Y. Sze George A. Poultsides John D. Louie 1 1 Mohammed A. Abdelrazek Mohammed David S. Wang Received: 16 November 2016 / Accepted: 4 April 2017 / Published online: 21 April 2017 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2017 Abstract before RE showed decreased levels after treatment (median Purpose Combined hepatocellular-cholangiocarcinoma decrease of 72%, range 13–80%). Best hepatic radiological (cHCC-CC) is a rare mixed cell type primary liver cancer response was 60% partial response and 40% stable disease with limited data to guide management. Transarterial by modiﬁed RECIST, and 100% stable disease by RECIST radioembolization with yttrium-90 microspheres (RE) is an v1.1. Poor performance status and the presence of emerging treatment option for both hepatocellular carci- macrovascular invasion were identiﬁed as predictors of noma and intrahepatic cholangiocarcinoma. This study reduced survival after RE. explored the safety and efﬁcacy of RE for unre- Conclusion RE appears to be a safe and promising treat- sectable cHCC-CC. ment option for patients with unresectable cHCC-CC.
CardioVascular and Interventional Radiology – Springer Journals
Published: Apr 21, 2017
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