Whole-genome sequence analysis of a Korean G11P(25) rotavirus strain identifies several porcine-human reassortant events

Whole-genome sequence analysis of a Korean G11P(25) rotavirus strain identifies several... A rare rotavirus, RVA/Human-wt/KOR/CAU12-2/2012/G11P(25), was isolated from a 16-year-old female with fever and diarrhea during the 2012 rotavirus surveillance in South Korea using a cell culture system, and its full genome sequence was determined and analyzed. Strain CAU12-2 exhibited a G11-P(25)-I12-R1-C1-M1-A1-N1-T1-E1-H1 genotype constellation. Phylogenetic analysis of this strain revealed that it is a human-porcine reassortant of two distant relatives of the G11 strains circulating in the world. The VP7 and VP4 genes are most closely related to those of human G11P(25) viruses (Dhaka6, KTM368, and N-38 strains) identified in South Asia, whereas the VP1 gene originated from a porcine G11P(7) virus (YM strain) that was identified in South America. The VP6 gene was found to belong to the new genotype I12. This study indicates that the G11-P(25)-I12 genotype was introduced into the South Korean population by interspecies transmissions of human and animal rotaviruses, followed by multiple reassortment events. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Whole-genome sequence analysis of a Korean G11P(25) rotavirus strain identifies several porcine-human reassortant events

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Publisher
Springer Vienna
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1720-9
Publisher site
See Article on Publisher Site

Abstract

A rare rotavirus, RVA/Human-wt/KOR/CAU12-2/2012/G11P(25), was isolated from a 16-year-old female with fever and diarrhea during the 2012 rotavirus surveillance in South Korea using a cell culture system, and its full genome sequence was determined and analyzed. Strain CAU12-2 exhibited a G11-P(25)-I12-R1-C1-M1-A1-N1-T1-E1-H1 genotype constellation. Phylogenetic analysis of this strain revealed that it is a human-porcine reassortant of two distant relatives of the G11 strains circulating in the world. The VP7 and VP4 genes are most closely related to those of human G11P(25) viruses (Dhaka6, KTM368, and N-38 strains) identified in South Asia, whereas the VP1 gene originated from a porcine G11P(7) virus (YM strain) that was identified in South America. The VP6 gene was found to belong to the new genotype I12. This study indicates that the G11-P(25)-I12 genotype was introduced into the South Korean population by interspecies transmissions of human and animal rotaviruses, followed by multiple reassortment events.

Journal

Archives of VirologySpringer Journals

Published: Nov 1, 2013

References

  • Genetic characterization of rotavirus in children in South Korea from 2007 to 2009
    Han, TH; Kim, CH; Chung, JY; Park, SH; Hwang, ES
  • Genotypic distribution of rotavirus strains causing severe gastroenteritis in Gyeonggi province, South Korea, from 2003 to 2005
    Huh, JW; Kim, WH; Yoon, MH; Lim, YH
  • Genotypes of the circulating rotavirus strains in the seven prevaccine seasons from September 2000 to August 2007 in South Korea
    Jeong, HS; Lee, KB; Jeong, AY; Jo, MY; Jung, SY; Ahn, JH; Jee, Y; Kim, J; Cheon, DS

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