Whole-genome analysis of porcine epidemic diarrhea virus (PEDV) from eastern China

Whole-genome analysis of porcine epidemic diarrhea virus (PEDV) from eastern China The complete genome sequence of a porcine epidemic diarrhea virus variant, strain SHQP/YM/2013, from China was determined and compared with those of other porcine epidemic diarrhea viruses. The full-length genome was 28,038 nucleotides (nt) in length without the poly (A) tail, and it was similar to that of other reported PEDV strains, with the characteristic gene order 5′-replicase (1a/1b) -S-ORF3-E-M-N-3′. Nucleotide sequence analysis based on individual virus genes indicated a close relationship between the S gene of SHQP/YM/2013 and those of the four Korean field strains from 2008–2009. Its ORF3 gene, however, fell into three groups. Recent prevalent Chinese PEDV field isolates were divided between group 1 and group 3, which suggests that the recent prevalent Chinese PEDV field isolates represent a new genotype that differs from the genotype that includes the vaccine strains. Based on phylogenetic analysis of the M gene, ORF3 gene and S gene, our study demonstrated that prevalent PEDV isolates in China may have originated from Korean strains. This report describes the complete genome sequence of SHQP/YM/2013, and the data will promote a better understanding of the molecular epidemiology and genetic diversity of PEDV field isolates in eastern China. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Whole-genome analysis of porcine epidemic diarrhea virus (PEDV) from eastern China

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-014-2102-7
Publisher site
See Article on Publisher Site

References

  • Molecular epidemiology of porcine epidemic diarrhea virus in China
    Chen, J; Wang, C; Shi, H; Qiu, H; Liu, S; Chen, X; Zhang, Z; Feng, L
  • Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence
    Kocherhans, R; Bridgen, A; Ackermann, M; Tobler, K

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