Whole genome analysis of a novel neurotropic bovine astrovirus detected in a Japanese black steer with non-suppurative encephalomyelitis in Japan

Whole genome analysis of a novel neurotropic bovine astrovirus detected in a Japanese black steer... While neurotropic bovine astroviruses (BoAstVs) have been identified in North America and Europe, their presence has never been reported in Asia. In this study, we detected BoAstV in the brain of a steer showing neurological signs. Phyloge- netic analysis revealed that the identified virus belongs to the Virginia/Human-Mink-Ovine clade, which contains most of the neurotropic astroviruses including the neurotropic BoAstVs. Similarity plot analysis showed that the virus was closely related to the American BoAstV NeuroS1 strain with respect to the ORF regions and to the European BoAstV CH13 strain in the 3′ untranslated region, suggesting the occurrence of intra-genotypic recombination events. Taxonomically, astroviruses (AstVs) can be classified within two genera, Mamastrovirus and Avastrovirus, that infect the family Astroviridae. They are primarily thought to have mammalian and avian hosts, respectively [2]. While the a fecal-oral route of transmission and have been identified mamastroviruses (MAstVs) have been recognized as impor- in a wide variety of host species [1, 2]. AstVs are small, tant etiological agents of gastroenteritis in humans, most icosahedral, non-enveloped virions, characterized by a MAstV strains have been detected in normal feces of healthy star-like surface structure, as observed under an electron animals [2]. MAstVs have also been associated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Whole genome analysis of a novel neurotropic bovine astrovirus detected in a Japanese black steer with non-suppurative encephalomyelitis in Japan

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Publisher
Springer Vienna
Copyright
Copyright © 2018 by Springer-Verlag GmbH Austria, part of Springer Nature
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-018-3898-3
Publisher site
See Article on Publisher Site

Abstract

While neurotropic bovine astroviruses (BoAstVs) have been identified in North America and Europe, their presence has never been reported in Asia. In this study, we detected BoAstV in the brain of a steer showing neurological signs. Phyloge- netic analysis revealed that the identified virus belongs to the Virginia/Human-Mink-Ovine clade, which contains most of the neurotropic astroviruses including the neurotropic BoAstVs. Similarity plot analysis showed that the virus was closely related to the American BoAstV NeuroS1 strain with respect to the ORF regions and to the European BoAstV CH13 strain in the 3′ untranslated region, suggesting the occurrence of intra-genotypic recombination events. Taxonomically, astroviruses (AstVs) can be classified within two genera, Mamastrovirus and Avastrovirus, that infect the family Astroviridae. They are primarily thought to have mammalian and avian hosts, respectively [2]. While the a fecal-oral route of transmission and have been identified mamastroviruses (MAstVs) have been recognized as impor- in a wide variety of host species [1, 2]. AstVs are small, tant etiological agents of gastroenteritis in humans, most icosahedral, non-enveloped virions, characterized by a MAstV strains have been detected in normal feces of healthy star-like surface structure, as observed under an electron animals [2]. MAstVs have also been associated

Journal

Archives of VirologySpringer Journals

Published: Jun 4, 2018

References

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