Short Communications Incorporating Mouse Genome Mammalian Genome 9, 469–471 (1998). © Springer-Verlag New York Inc. 1998 B-w White-based brown (Tyrp1 ) is a dominant mutation causing reduced hair pigmentation owing to a chromosomal inversion Sophie Javerzat,* Ian J. Jackson MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH 2XU, UK Received: 19 December 1997 / Accepted: 14 February 1998 B-w The white-based brown (Tyrp1 ) mutation of the tyrosinase- related protein-1 (Tyrp1) or brown locus arose during a radiation mutagenesis experiment, following exposure of a (101/R1 × C3H/ R1) F male to 600 rad (6Gy) of g-radiation over a period of several weeks (Hunsicker 1969). As the name indicates, there is an absence or reduction in pigment at the base of the hair. The white base is dominant, that is, it is visible when heterozygous with wild-type Tyrp1, although it extends over a larger part of the hair B-w in Tyrp1 homozygotes. The pigment that is produced when B-w B-w Fig. 1. Structure of the Tyrp1 locus and inverse PCR. Schematic rep- Tyrp1 is homozygous or is heterozygous with the loss of func- b resentation of the white-based brown mutation at the Tyrp1 locus. Only the tion
Mammalian Genome – Springer Journals
Published: Jun 1, 1998
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