Aging Clinical and Experimental Research https://doi.org/10.1007/s40520-018-0982-1 C ASE REPOR T 1 1 2 2 1 2 Alberto Castagna · Pietro Gareri · Francesca Falvo · Simona Sestito · Maurizio Rocca · Licia Pensabene · 2 4 3 Daniela Concolino · Giuseppe Coppolino · Giovanni Ruotolo Received: 21 February 2018 / Accepted: 30 May 2018 © Springer International Publishing AG, part of Springer Nature 2018 Keywords Werner syndrome · Diabetes mellitus · Hypercholesterolemia · Progeroid syndrome · Atherosclerosis Introduction Case report Werner syndrome (WS) is a premature progeroid syndrome A 55-year-old woman was visited 5 days following suspected characterized by early onset of age-related diseases, such as transient ischemic attack. At present, she was hospitalized in atherosclerosis, cancer predisposition, osteoporosis, type 2 a nursing home and suddenly presented difficulty in under - diabetes mellitus, skin ulcers, and ocular cataracts [1, 2]. It is standing words and articulating a speech. Symptoms lasted a rare autosomal recessive disorder of remarkable biomedi- about 20 min and were followed by about 5 h psychomotor cal interest, because patients exhibit an accelerated develop- slowdown, regressed within 12 h. Metabolic and hemody- ment of several major disorders commonly found in older namic parameters were normal. people. WRN is the gene responsible for the disease and Clinical history suggested hypercholesterolemia since encodes a RecQ-type
Aging Clinical and Experimental Research – Springer Journals
Published: Jun 6, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera