Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine hybrids

Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine... Keywords 1,2,3-Triazole  1,4-Dihydropyridine  Hybrids  Water mediated Anti-bacterial  Anti-inflammatory Introduction 1,4-Dihydropyridines (1,4-DHPs) have been used for the treatment of cardiovas- cular disease [1] and hypertension [2, 3]. They also show a broad range of pharmacological action in bronchodilaton, vasodilation, hepatoprotection, geropro- tection and exhibit bioactivities such as in the antitumor, antimutagenic, antiatherosclerotic, antidiabetic activities [4, 5]. Some commercially available drugs, which contain 1,4-DHP core are Nifedipine, Amlodipine, Lacidipine, Isradipine, Nimodipine, Nisoldipine, and lercenadipine (Fig. 1). On the other hand, 1,2,3-triazoles show bioactivities such as antibacterial, herbicidal, fungicidal, and anti-HIV activities [6–9]. Recent studies are being oriented towards the synthesis of hybrid bioactive compounds, the molecular frameworks of which are made up of two or more heterocyclic scaffolds. It has been reported that the combination of two heterocyclic skeletons having different biological functions produce new hybrid compounds that are more medically effective than their parent molecules [10]. In this regard, we have reported commendable bioactivities of 1,2,3-triazolyl-2-aminopyrimidine hybrids and 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids [11, 12]. A similar report by Kumbhare et al. [13] deals with the synthesis of a dihydropyridine-1,2,3-triazole hybrids and their ACE inhibitory activity. This report discloses that the 1,2,3-triazole moiety has a pronounced effect in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine hybrids

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2614-8
Publisher site
See Article on Publisher Site

Abstract

Keywords 1,2,3-Triazole  1,4-Dihydropyridine  Hybrids  Water mediated Anti-bacterial  Anti-inflammatory Introduction 1,4-Dihydropyridines (1,4-DHPs) have been used for the treatment of cardiovas- cular disease [1] and hypertension [2, 3]. They also show a broad range of pharmacological action in bronchodilaton, vasodilation, hepatoprotection, geropro- tection and exhibit bioactivities such as in the antitumor, antimutagenic, antiatherosclerotic, antidiabetic activities [4, 5]. Some commercially available drugs, which contain 1,4-DHP core are Nifedipine, Amlodipine, Lacidipine, Isradipine, Nimodipine, Nisoldipine, and lercenadipine (Fig. 1). On the other hand, 1,2,3-triazoles show bioactivities such as antibacterial, herbicidal, fungicidal, and anti-HIV activities [6–9]. Recent studies are being oriented towards the synthesis of hybrid bioactive compounds, the molecular frameworks of which are made up of two or more heterocyclic scaffolds. It has been reported that the combination of two heterocyclic skeletons having different biological functions produce new hybrid compounds that are more medically effective than their parent molecules [10]. In this regard, we have reported commendable bioactivities of 1,2,3-triazolyl-2-aminopyrimidine hybrids and 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids [11, 12]. A similar report by Kumbhare et al. [13] deals with the synthesis of a dihydropyridine-1,2,3-triazole hybrids and their ACE inhibitory activity. This report discloses that the 1,2,3-triazole moiety has a pronounced effect in

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 24, 2016

References

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