Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine hybrids

Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine... Keywords 1,2,3-Triazole  1,4-Dihydropyridine  Hybrids  Water mediated Anti-bacterial  Anti-inflammatory Introduction 1,4-Dihydropyridines (1,4-DHPs) have been used for the treatment of cardiovas- cular disease [1] and hypertension [2, 3]. They also show a broad range of pharmacological action in bronchodilaton, vasodilation, hepatoprotection, geropro- tection and exhibit bioactivities such as in the antitumor, antimutagenic, antiatherosclerotic, antidiabetic activities [4, 5]. Some commercially available drugs, which contain 1,4-DHP core are Nifedipine, Amlodipine, Lacidipine, Isradipine, Nimodipine, Nisoldipine, and lercenadipine (Fig. 1). On the other hand, 1,2,3-triazoles show bioactivities such as antibacterial, herbicidal, fungicidal, and anti-HIV activities [6–9]. Recent studies are being oriented towards the synthesis of hybrid bioactive compounds, the molecular frameworks of which are made up of two or more heterocyclic scaffolds. It has been reported that the combination of two heterocyclic skeletons having different biological functions produce new hybrid compounds that are more medically effective than their parent molecules [10]. In this regard, we have reported commendable bioactivities of 1,2,3-triazolyl-2-aminopyrimidine hybrids and 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids [11, 12]. A similar report by Kumbhare et al. [13] deals with the synthesis of a dihydropyridine-1,2,3-triazole hybrids and their ACE inhibitory activity. This report discloses that the 1,2,3-triazole moiety has a pronounced effect in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine hybrids

Loading next page...
 
/lp/springer_journal/water-mediated-one-pot-synthesis-and-biological-evaluation-of-1-2-3-hcjZAZJI9t
Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2614-8
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial