Reactions 1704, p371 - 2 Jun 2018 Gastrointestinal bleeding: case report In a case series of three patients, a woman [age at the reaction onset not stated] was described who developed upper gastrointestinal bleeding during treatment with warfarin for deep vein thrombosis (DVT) and antiphospholipid syndrome [dosage, route and outcome not stated]. The woman was diagnosed with DVT in the right femoral vein at 28 years of age, following a third miscarriage in February 1999. She also had antiphospholipid syndrome. Subsequently, she started receiving warfarin treatment. Antiphospholipid antibody IgG first became negative in July 2005. After 124 months of anticoagulation, in April 2010, she developed upper gastrointestinal bleeding. Therefore, warfarin was discontinued due to the ADR. The woman decided to stop warfarin permanently. During the follow-ups, no new thrombotic events occurred. Author comment: "Our second case who presented with recurrent miscarriage and DVT had an upper gastrointestinal bleeding 124 months after anticoagulation. We stopped warfarin until the bleeding risk was controlled, but the patient made a personal decision to halt warfarin." Hindilerden F, et al. Could anticoagulation or antiaggregation treatment be ceased in patients with primary antiphospholipid syndrome when antiphospholipid antibodies become persistently negative?. JCR: Journal of Clinical Rheumatology 23: 350-353, No. 6, Sep 2017. Available from: URL: http://doi.org/10.1097/ RHU.0000000000000538 - Turkey 803324017 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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