Vortioxetine Reactions 1680, p338 - 2 Dec 2017 Hyponatraemia complicated by flutter and thromboembolic stroke: case report A 72-year-old woman developed hyponatraemia complicated by flutter and thromboembolic stroke, and died during treatment with vortioxetine [route not stated]. The woman was evaluated for low mood, loss of interest, anhedonia, tiredness, little concentration and decreased activity in March 2016. Since the age of 55 years, she had a history of recurrent depressive disorder with multiple prior hospitalisations. The hospitalisations were due to severe hyponatraemia associated with different psychotropic drugs. Currently, she was on a treatment with maprotiline. Vortioxetine 5mg was added to the therapy, which was then maintained at 10 mg/day after four weeks. Twenty six days later, she was admitted to the ICU from the emergency department, after presenting with a seizure. After 13 days of the admission, despite recovering sodium levels, she presented with a decreased level of consciousness. She was given a diagnosis of thromboembolic stroke as a complication of a flutter. She had developed flutter during the initial days of the therapy. The woman died few minutes after presenting with asystole and agonic respiration, despite resuscitation attempts. Author comment: As for the risk, we have observed a fatal case of hyponatremia associated with the use of vortioxetine in our hospital. [P]roposing as diagnosis a thromboembolic stroke as a complication of a flutter suffered during the first days. Pelayo-Teran JM, et al. Safety in the use of antidepressants: Vortioxetine-induce hyponatremia in a case report. Revista de Psiquiatria y Salud Mental 10: 219-220, No. 4, Oct-Dec 2017. Available from: URL: http://doi.org/10.1016/ j.rpsm.2017.07.001 [Spanish; summarised from a translation] - Spain 803285474 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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