Reactions 1704, p369 - 2 Jun 2018
Severe hyponatraemia: case report
An 82-year-old man developed severe hyponatraemia
during treatment with voriconazole for Scedosporium
apiospermum infection [duration of treatment to reaction
onset not stated].
The man who had progressive pruriginous lesions on the
dorsal side of his left hand, received treatment with an
unspecified topical antifungal agent and oral antibiotics.
However, his symptoms persisted. Hence, he presented to
hospital. On presentation, his examination revealed
sporotrichoid lymphocutaneous fungal infection due to
Scedosporium apiospermum. The man was admitted and his
treatment was initiated with oral voriconazole
400 mg/12 hours on day 1 followed by 200 mg/12 hours on
the subsequent days. During the treatment, a severe
hyponatraemia attributed to voriconazole was noted.
The man was treated with electrolyte therapy and fluids.
Treatment with voriconazole was held temporarily.
Subsequently, the hyponatraemia resolved gradually.
Author comment: "During admission, the most
remarkable observation was severe voriconazole-induced
hyponatremia, which resolved gradually with fluid and
electrolyte therapy and temporary suspension of the drug."
Company-Quiroga J, et al. Bullous Necrotic Purpura Caused by Scedosporium
apiospermum Presenting With a Sporotrichoid Pattern. Actas Dermo-Sifiliograficas
109: 374-376, No. 4, May 2018. Available from: URL: http://doi.org/10.1016/
j.adengl.2018.03.008 - Spain
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved