Voriconazole

Voriconazole Reactions 1704, p369 - 2 Jun 2018 Severe hyponatraemia: case report An 82-year-old man developed severe hyponatraemia during treatment with voriconazole for Scedosporium apiospermum infection [duration of treatment to reaction onset not stated]. The man who had progressive pruriginous lesions on the dorsal side of his left hand, received treatment with an unspecified topical antifungal agent and oral antibiotics. However, his symptoms persisted. Hence, he presented to hospital. On presentation, his examination revealed sporotrichoid lymphocutaneous fungal infection due to Scedosporium apiospermum. The man was admitted and his treatment was initiated with oral voriconazole 400 mg/12 hours on day 1 followed by 200 mg/12 hours on the subsequent days. During the treatment, a severe hyponatraemia attributed to voriconazole was noted. The man was treated with electrolyte therapy and fluids. Treatment with voriconazole was held temporarily. Subsequently, the hyponatraemia resolved gradually. Author comment: "During admission, the most remarkable observation was severe voriconazole-induced hyponatremia, which resolved gradually with fluid and electrolyte therapy and temporary suspension of the drug." Company-Quiroga J, et al. Bullous Necrotic Purpura Caused by Scedosporium apiospermum Presenting With a Sporotrichoid Pattern. Actas Dermo-Sifiliograficas 109: 374-376, No. 4, May 2018. Available from: URL: http://doi.org/10.1016/ j.adengl.2018.03.008 - Spain 803323970 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Voriconazole

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-47012-7
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p369 - 2 Jun 2018 Severe hyponatraemia: case report An 82-year-old man developed severe hyponatraemia during treatment with voriconazole for Scedosporium apiospermum infection [duration of treatment to reaction onset not stated]. The man who had progressive pruriginous lesions on the dorsal side of his left hand, received treatment with an unspecified topical antifungal agent and oral antibiotics. However, his symptoms persisted. Hence, he presented to hospital. On presentation, his examination revealed sporotrichoid lymphocutaneous fungal infection due to Scedosporium apiospermum. The man was admitted and his treatment was initiated with oral voriconazole 400 mg/12 hours on day 1 followed by 200 mg/12 hours on the subsequent days. During the treatment, a severe hyponatraemia attributed to voriconazole was noted. The man was treated with electrolyte therapy and fluids. Treatment with voriconazole was held temporarily. Subsequently, the hyponatraemia resolved gradually. Author comment: "During admission, the most remarkable observation was severe voriconazole-induced hyponatremia, which resolved gradually with fluid and electrolyte therapy and temporary suspension of the drug." Company-Quiroga J, et al. Bullous Necrotic Purpura Caused by Scedosporium apiospermum Presenting With a Sporotrichoid Pattern. Actas Dermo-Sifiliograficas 109: 374-376, No. 4, May 2018. Available from: URL: http://doi.org/10.1016/ j.adengl.2018.03.008 - Spain 803323970 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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