Volume expansion of periaqueductal gray in episodic migraine: a pilot MRI structural imaging study

Volume expansion of periaqueductal gray in episodic migraine: a pilot MRI structural imaging study Background: The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the nonspecific PAG lesions were also observed in episodic migraine (EM) recently. However, the PAG volume change was not totally detected in EM up to now. Herein, the aim of this study was to investigate altered PAG volume in EM patients based on high resolution brain structural image. Methods: The brain structural images were obtained from 18 normal controls (NC), 18 EM patients and 16 chronic migraine (CM) on 3.0 T MR system. PAG template was created based on the ICBM152 gray matter template using MRIcron, and the individual PAG was created by applying the deformation field to the PAG template after structural image segment. One-way analysis of covariance, partial correlation analysis and Receiver operating characteristics (ROC) curve were applied. Results: EM had a larger PAG volume (0.35 ± 0.02 ml) than that (0.32 ± 0.02 ml) of NC (P = 0.017). The PAG volume of CM (0.33 ± 0.02 ml) was negatively related to the VAS score (P = 0.03). ROC analysis demonstrated that PAG volume has higher diagnostic efficacy (AUC, 0.731; Sensitivity, 0.556; Specificity, 0.889) for NC vs. EM compared with that NC vs. CM (AUC, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Headache and Pain Springer Journals

Volume expansion of periaqueductal gray in episodic migraine: a pilot MRI structural imaging study

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Springer Milan
Copyright © 2017 by The Author(s).
Medicine & Public Health; Pain Medicine; Internal Medicine; Neurology
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