J. Membrane Biol. 184, 1–12 (2001) The Journal of DOI: 10.1007/s00232-001-0077-2 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues H. Duclohier, H. Wro ´ blewski Interactions Cellulaires et Mole ´culaires, UMR CNRS 6026, Universite ´ de Rennes I, Campus de Beaulieu, 35042 Rennes Cedex, France Received: 30 June 2001 Introduction mentioned above , alamethicin single-channel events were recorded with multiple open states  and their Despite the long-standing interest for membrane-active detailed kinetic analysis led to the proposition of the peptides, alamethicin remains the best studied simple ‘barrel-stave’ model . In the early eighties, the high- model of pores formed by the intramembrane aggrega- resolution (down to 1.5 Å) crystallographic structure of tion of amphipathic a-helices. The demonstration of ar- alamethicin  was a landmark, from which new struc- tificial membrane excitability developed by planar lipid tural studies sprang also allowing the formulation of hy- bilayers doped with alamethicin  indeed struck the potheses on the voltage-dependent membrane insertion minds of many a biophysicist, including electrophysiolo- and the architecture of the oligomeric channel. gists, at a time when the protein nature of ion channels The purpose of
The Journal of Membrane Biology – Springer Journals
Published: Nov 1, 2001
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