Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues

Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues J. Membrane Biol. 184, 1–12 (2001) The Journal of DOI: 10.1007/s00232-001-0077-2 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues H. Duclohier, H. Wro ´ blewski Interactions Cellulaires et Mole ´culaires, UMR CNRS 6026, Universite ´ de Rennes I, Campus de Beaulieu, 35042 Rennes Cedex, France Received: 30 June 2001 Introduction mentioned above [70], alamethicin single-channel events were recorded with multiple open states [38] and their Despite the long-standing interest for membrane-active detailed kinetic analysis led to the proposition of the peptides, alamethicin remains the best studied simple ‘barrel-stave’ model [12]. In the early eighties, the high- model of pores formed by the intramembrane aggrega- resolution (down to 1.5 Å) crystallographic structure of tion of amphipathic a-helices. The demonstration of ar- alamethicin [33] was a landmark, from which new struc- tificial membrane excitability developed by planar lipid tural studies sprang also allowing the formulation of hy- bilayers doped with alamethicin [70] indeed struck the potheses on the voltage-dependent membrane insertion minds of many a biophysicist, including electrophysiolo- and the architecture of the oligomeric channel. gists, at a time when the protein nature of ion channels The purpose of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues

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Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 2001 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-001-0077-2
Publisher site
See Article on Publisher Site

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