Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues

Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues J. Membrane Biol. 184, 1–12 (2001) The Journal of DOI: 10.1007/s00232-001-0077-2 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues H. Duclohier, H. Wro ´ blewski Interactions Cellulaires et Mole ´culaires, UMR CNRS 6026, Universite ´ de Rennes I, Campus de Beaulieu, 35042 Rennes Cedex, France Received: 30 June 2001 Introduction mentioned above [70], alamethicin single-channel events were recorded with multiple open states [38] and their Despite the long-standing interest for membrane-active detailed kinetic analysis led to the proposition of the peptides, alamethicin remains the best studied simple ‘barrel-stave’ model [12]. In the early eighties, the high- model of pores formed by the intramembrane aggrega- resolution (down to 1.5 Å) crystallographic structure of tion of amphipathic a-helices. The demonstration of ar- alamethicin [33] was a landmark, from which new struc- tificial membrane excitability developed by planar lipid tural studies sprang also allowing the formulation of hy- bilayers doped with alamethicin [70] indeed struck the potheses on the voltage-dependent membrane insertion minds of many a biophysicist, including electrophysiolo- and the architecture of the oligomeric channel. gists, at a time when the protein nature of ion channels The purpose of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues

Loading next page...
 
/lp/springer_journal/voltage-dependent-pore-formation-and-antimicrobial-activity-by-0dlYzwhl0V
Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 2001 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-001-0077-2
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 184, 1–12 (2001) The Journal of DOI: 10.1007/s00232-001-0077-2 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review Voltage-Dependent Pore Formation and Antimicrobial Activity by Alamethicin and Analogues H. Duclohier, H. Wro ´ blewski Interactions Cellulaires et Mole ´culaires, UMR CNRS 6026, Universite ´ de Rennes I, Campus de Beaulieu, 35042 Rennes Cedex, France Received: 30 June 2001 Introduction mentioned above [70], alamethicin single-channel events were recorded with multiple open states [38] and their Despite the long-standing interest for membrane-active detailed kinetic analysis led to the proposition of the peptides, alamethicin remains the best studied simple ‘barrel-stave’ model [12]. In the early eighties, the high- model of pores formed by the intramembrane aggrega- resolution (down to 1.5 Å) crystallographic structure of tion of amphipathic a-helices. The demonstration of ar- alamethicin [33] was a landmark, from which new struc- tificial membrane excitability developed by planar lipid tural studies sprang also allowing the formulation of hy- bilayers doped with alamethicin [70] indeed struck the potheses on the voltage-dependent membrane insertion minds of many a biophysicist, including electrophysiolo- and the architecture of the oligomeric channel. gists, at a time when the protein nature of ion channels The purpose of

Journal

The Journal of Membrane BiologySpringer Journals

Published: Nov 1, 2001

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off