J. Membrane Biol. 155, 105–112 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review 1 2 3 R.F. Rakowski , D.C. Gadsby , P. De Weer Department of Physiology and Biophysics, Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL 60064, USA Laboratory of Cardiac/Membrane Physiology, The Rockefeller University, New York, NY 10021, USA Department of Physiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA Received: 2 August 1996/Revised: 13 September 1996 Introduction 1988b; Apell, 1989; Apell, 1990; Glynn & Karlish, 1990; Horisberger et al., 1991; Bamberg et al., 1993; Whether Na/K pump rate is influenced by membrane Glynn, 1993; Vasilets & Schwarz, 1993). This review potential was still debated as recently as 1988 (De Weer, will briefly summarize recent studies on the voltage de- Gadsby & Rakowski, 1988). While it follows from first pendence of the Na/K pump. A recurrent theme in recent principles that the rate of net forward Na/K pumping work is the external access channel or ‘‘ion well’’ hy- must vanish with hyperpolarization as the thermody- pothesis. There are only two ways that net transport can namic reversal potential of the overall pump reaction is be
The Journal of Membrane Biology – Springer Journals
Published: Jan 15, 1997
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