Voltage Dependence of Open Channel Blockade: Onset and Offset Rates

Voltage Dependence of Open Channel Blockade: Onset and Offset Rates J. Membrane Biol. 161, 1–8 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review D.B. Tikhonov, L.G. Magazanik Laboratory of Biophysics, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia Received: 6 May 1997/ Revised: 17 July 1997 Introduction For instance, the blockade of mechanosensitive channels by amiloride depends on voltage, which is negligible at positive potentials. It has been found that the permeant It is well known that open ion channels can bind different ions do not change the voltage dependence in this case drugs at the pore, and this kind of interaction impedes the (Lane, McBride & Hamill, 1993). Nevertheless, the ex- ion flux through the channel. In many cases, the block is perimental curve of voltage dependence cannot be de- dependent on the transmembrane potential difference. scribed by the Woodhull model and is consistent with a This article discusses the practical application and limits voltage-independent binding of the drug to a site that is of models used for describing such block. accessible at hyperpolarized but not at depolarized po- Any voltage dependence of block must be due to the tentials (Rusch, Kros & Richardson, 1994). The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Voltage Dependence of Open Channel Blockade: Onset and Offset Rates

Loading next page...
 
/lp/springer_journal/voltage-dependence-of-open-channel-blockade-onset-and-offset-rates-SQzYHhxZCb
Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 1998 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900309
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial