Voltage Dependence of Open Channel Blockade: Onset and Offset Rates

Voltage Dependence of Open Channel Blockade: Onset and Offset Rates J. Membrane Biol. 161, 1–8 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review D.B. Tikhonov, L.G. Magazanik Laboratory of Biophysics, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia Received: 6 May 1997/ Revised: 17 July 1997 Introduction For instance, the blockade of mechanosensitive channels by amiloride depends on voltage, which is negligible at positive potentials. It has been found that the permeant It is well known that open ion channels can bind different ions do not change the voltage dependence in this case drugs at the pore, and this kind of interaction impedes the (Lane, McBride & Hamill, 1993). Nevertheless, the ex- ion flux through the channel. In many cases, the block is perimental curve of voltage dependence cannot be de- dependent on the transmembrane potential difference. scribed by the Woodhull model and is consistent with a This article discusses the practical application and limits voltage-independent binding of the drug to a site that is of models used for describing such block. accessible at hyperpolarized but not at depolarized po- Any voltage dependence of block must be due to the tentials (Rusch, Kros & Richardson, 1994). The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Voltage Dependence of Open Channel Blockade: Onset and Offset Rates

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Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 1998 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900309
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 161, 1–8 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review D.B. Tikhonov, L.G. Magazanik Laboratory of Biophysics, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia Received: 6 May 1997/ Revised: 17 July 1997 Introduction For instance, the blockade of mechanosensitive channels by amiloride depends on voltage, which is negligible at positive potentials. It has been found that the permeant It is well known that open ion channels can bind different ions do not change the voltage dependence in this case drugs at the pore, and this kind of interaction impedes the (Lane, McBride & Hamill, 1993). Nevertheless, the ex- ion flux through the channel. In many cases, the block is perimental curve of voltage dependence cannot be de- dependent on the transmembrane potential difference. scribed by the Woodhull model and is consistent with a This article discusses the practical application and limits voltage-independent binding of the drug to a site that is of models used for describing such block. accessible at hyperpolarized but not at depolarized po- Any voltage dependence of block must be due to the tentials (Rusch, Kros & Richardson, 1994). The

Journal

The Journal of Membrane BiologySpringer Journals

Published: Jan 1, 1998

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