J. Membrane Biol. 161, 1–8 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review D.B. Tikhonov, L.G. Magazanik Laboratory of Biophysics, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia Received: 6 May 1997/ Revised: 17 July 1997 Introduction For instance, the blockade of mechanosensitive channels by amiloride depends on voltage, which is negligible at positive potentials. It has been found that the permeant It is well known that open ion channels can bind different ions do not change the voltage dependence in this case drugs at the pore, and this kind of interaction impedes the (Lane, McBride & Hamill, 1993). Nevertheless, the ex- ion flux through the channel. In many cases, the block is perimental curve of voltage dependence cannot be de- dependent on the transmembrane potential difference. scribed by the Woodhull model and is consistent with a This article discusses the practical application and limits voltage-independent binding of the drug to a site that is of models used for describing such block. accessible at hyperpolarized but not at depolarized po- Any voltage dependence of block must be due to the tentials (Rusch, Kros & Richardson, 1994). The
The Journal of Membrane Biology – Springer Journals
Published: Jan 1, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera