Curr Fungal Infect Rep (2017) 11:117–123 DOI 10.1007/s12281-017-0284-7 ADVANCES IN DIAGNOSIS OF INVASIVE FUNGAL INFECTIONS (S CHEN, SECTION EDITOR) Volatile Organic Compounds: Upcoming Role in Diagnosis of Invasive Mould Infections 1 1,2 Amy Scott-Thomas & Stephen T. Chambers Published online: 24 July 2017 Springer Science+Business Media, LLC 2017 Abstract Keywords Volatile organic compounds Fungal respiratory . . . Purpose of Review Breath testing for fungal respiratory infec- infections ICU Aspergillus fumigatus Diagnosis tions has great promise as samples can be obtained by non- invasive, repeatable techniques that can be done on a wide range of patients including children, the confused and from Introduction those in the intensive care unit (ICU). We have reviewed progress toward development of test applicable to clinical Invasive filamentous fungal infections are uncommon but practice. may cause acute, severe, life-threatening infections in the Recent Findings Many volatile organic compounds (VOCs) immune-compromised host. Aspergillus fumigatus is the most have been identified, especially from key pathogens such as common mould infection worldwide in neutropenic patients, Aspergillus fumigatus, but very few clinical trials have been in whom the incidence parallels the duration and severity of performed. The most convincing of these demonstrated that the neutropenia, and solid organ
Current Fungal Infection Reports – Springer Journals
Published: Jul 24, 2017
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