Summary The anti-oxidative effects of vitamin D3 (Vd3) on mesenchymal stem cells (MSCs) have not been studied before. The present study suggested that Vd3 could not only promote the osteogenic differentiation of MSCs under normal condition but also partly protect it from oxidative stress damage by activating the endogenous antioxidant system. Introduction Evolving evidence proved that oxidative stress caused by reactive oxygen species (ROS) overproduction might lead to bone loss. Vd3, a commonly used osteogenic induction drug, was proved to exhibit potent anti-oxidative effects on other cell types. The present study aims to investigate the protective effects of Vd3 on oxidative stress-induced dysfunctions of MSCs, as well as its underlying mechanisms. Methods The H O was used as exogenous reactive oxygen species (ROS). The influence of ROS and anti-oxidative protection 2 2 of Vd3 on MSCs were analyzed too. Multi-techniques were used to assess the beneficial effects of Vd3 on MSCs under oxidative stress condition. Results The results demonstrated that Vd3 could significantly attenuate the H O -induced cell injury of MSCs via Sirt1/FoxO1 2 2 signaling pathway, and reduced the H O exposure-induced intracellular oxidative stress status of MSCs. What’smore, theH O 2 2 2 2 exposure resulted
Osteoporosis International – Springer Journals
Published: Jun 2, 2018
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