Vitamin D3 contributes to enhanced osteogenic differentiation of MSCs under oxidative stress condition via activating the endogenous antioxidant system

Vitamin D3 contributes to enhanced osteogenic differentiation of MSCs under oxidative stress... Summary The anti-oxidative effects of vitamin D3 (Vd3) on mesenchymal stem cells (MSCs) have not been studied before. The present study suggested that Vd3 could not only promote the osteogenic differentiation of MSCs under normal condition but also partly protect it from oxidative stress damage by activating the endogenous antioxidant system. Introduction Evolving evidence proved that oxidative stress caused by reactive oxygen species (ROS) overproduction might lead to bone loss. Vd3, a commonly used osteogenic induction drug, was proved to exhibit potent anti-oxidative effects on other cell types. The present study aims to investigate the protective effects of Vd3 on oxidative stress-induced dysfunctions of MSCs, as well as its underlying mechanisms. Methods The H O was used as exogenous reactive oxygen species (ROS). The influence of ROS and anti-oxidative protection 2 2 of Vd3 on MSCs were analyzed too. Multi-techniques were used to assess the beneficial effects of Vd3 on MSCs under oxidative stress condition. Results The results demonstrated that Vd3 could significantly attenuate the H O -induced cell injury of MSCs via Sirt1/FoxO1 2 2 signaling pathway, and reduced the H O exposure-induced intracellular oxidative stress status of MSCs. What’smore, theH O 2 2 2 2 exposure resulted http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Osteoporosis International Springer Journals

Vitamin D3 contributes to enhanced osteogenic differentiation of MSCs under oxidative stress condition via activating the endogenous antioxidant system

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Publisher
Springer Journals
Copyright
Copyright © 2018 by International Osteoporosis Foundation and National Osteoporosis Foundation
Subject
Medicine & Public Health; Orthopedics; Endocrinology; Rheumatology
ISSN
0937-941X
eISSN
1433-2965
D.O.I.
10.1007/s00198-018-4547-0
Publisher site
See Article on Publisher Site

Abstract

Summary The anti-oxidative effects of vitamin D3 (Vd3) on mesenchymal stem cells (MSCs) have not been studied before. The present study suggested that Vd3 could not only promote the osteogenic differentiation of MSCs under normal condition but also partly protect it from oxidative stress damage by activating the endogenous antioxidant system. Introduction Evolving evidence proved that oxidative stress caused by reactive oxygen species (ROS) overproduction might lead to bone loss. Vd3, a commonly used osteogenic induction drug, was proved to exhibit potent anti-oxidative effects on other cell types. The present study aims to investigate the protective effects of Vd3 on oxidative stress-induced dysfunctions of MSCs, as well as its underlying mechanisms. Methods The H O was used as exogenous reactive oxygen species (ROS). The influence of ROS and anti-oxidative protection 2 2 of Vd3 on MSCs were analyzed too. Multi-techniques were used to assess the beneficial effects of Vd3 on MSCs under oxidative stress condition. Results The results demonstrated that Vd3 could significantly attenuate the H O -induced cell injury of MSCs via Sirt1/FoxO1 2 2 signaling pathway, and reduced the H O exposure-induced intracellular oxidative stress status of MSCs. What’smore, theH O 2 2 2 2 exposure resulted

Journal

Osteoporosis InternationalSpringer Journals

Published: Jun 2, 2018

References

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