Vismodegib and risk of cholestatic injury: should we screen candidate patients?

Vismodegib and risk of cholestatic injury: should we screen candidate patients? Clin Exp Med (2017) 17:415–416 DOI 10.1007/s10238-016-0433-2 LETTER TO THE EDITOR Vismodegib and risk of cholestatic injury: should we screen candidate patients? 1 2 1 2 • • • • Michelangelo Vestita Lucia Lospalluti Giuseppe Giudice Domenico Bonamonte 3 2 Ignazio Rossiello Angela Filoni Received: 15 July 2016 / Accepted: 24 July 2016 / Published online: 2 August 2016 Springer International Publishing Switzerland 2016 Dear Sir, tomography, magnetic resonance imaging and endoscopic retrograde cholangiopancreatography. Periportal edema, We have read with interest the paper of Ash et al. [1] along with increased liver volume and mild dilatation of concerning vismodegib-related cholestatic liver injury. We the intrahepatic bile ducts, was noticed (Fig. 1). Minute would like to report our experience with a 71-year-old lithiasic formations were present in the gallbladder, patient who underwent vismodegib therapy for 11 spread choledochus and cystic duct (Fig. 2; Suppl Fig. 1, 2). A cutaneous basal cell carcinoma, of which 4 were recurring single, larger, previously documented, 15 mm lithiasic lesions, and developed intense jaundice by severe element was also evident in the gallbladder. Ash et al. [1] cholestasis and acute liver injury after 3 months of vis- reason on the potential ability of vismodegib to Clinical and Experimental Medicine Springer Journals

Vismodegib and risk of cholestatic injury: should we screen candidate patients?

Loading next page...
Springer International Publishing
Copyright © 2016 by Springer International Publishing Switzerland
Medicine & Public Health; Internal Medicine; Hematology; Oncology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial