Vismodegib and risk of cholestatic injury: should we screen candidate patients?

Vismodegib and risk of cholestatic injury: should we screen candidate patients? Clin Exp Med (2017) 17:415–416 DOI 10.1007/s10238-016-0433-2 LETTER TO THE EDITOR Vismodegib and risk of cholestatic injury: should we screen candidate patients? 1 2 1 2 • • • • Michelangelo Vestita Lucia Lospalluti Giuseppe Giudice Domenico Bonamonte 3 2 Ignazio Rossiello Angela Filoni Received: 15 July 2016 / Accepted: 24 July 2016 / Published online: 2 August 2016 Springer International Publishing Switzerland 2016 Dear Sir, tomography, magnetic resonance imaging and endoscopic retrograde cholangiopancreatography. Periportal edema, We have read with interest the paper of Ash et al. [1] along with increased liver volume and mild dilatation of concerning vismodegib-related cholestatic liver injury. We the intrahepatic bile ducts, was noticed (Fig. 1). Minute would like to report our experience with a 71-year-old lithiasic formations were present in the gallbladder, patient who underwent vismodegib therapy for 11 spread choledochus and cystic duct (Fig. 2; Suppl Fig. 1, 2). A cutaneous basal cell carcinoma, of which 4 were recurring single, larger, previously documented, 15 mm lithiasic lesions, and developed intense jaundice by severe element was also evident in the gallbladder. Ash et al. [1] cholestasis and acute liver injury after 3 months of vis- reason on the potential ability of vismodegib to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Experimental Medicine Springer Journals

Vismodegib and risk of cholestatic injury: should we screen candidate patients?

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Publisher
Springer International Publishing
Copyright
Copyright © 2016 by Springer International Publishing Switzerland
Subject
Medicine & Public Health; Internal Medicine; Hematology; Oncology
ISSN
1591-8890
eISSN
1591-9528
D.O.I.
10.1007/s10238-016-0433-2
Publisher site
See Article on Publisher Site

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