Virulence domain of the RYMV genome-linked viral protein VPg towards rice rymv 1–2-mediated resistance

Virulence domain of the RYMV genome-linked viral protein VPg towards rice rymv 1–2-mediated... Virulent variants of Rice yellow mottle virus (genus Sobemovirus ) can emerge on the highly resistant rice cultivars Gigante and Bekarosaka. Non-synonymous mutations responsible for the breakdown of the recessive resistance gene rymv 1–2 were located in the VPg after determination of its termini in the polyprotein P2a. The secondary structure of this protein was predicted to include a central α-helix. The two major amino acids related to virulence are located on the same side of this helix. The 3D topology and the biochemical properties of virulence mutations both suggested a direct site-to-site interaction between RYMV VPg and rice eIF(iso)4G encoded by rymv 1. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Virulence domain of the RYMV genome-linked viral protein VPg towards rice rymv 1–2-mediated resistance

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Publisher
Springer Vienna
Copyright
Copyright © 2008 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-008-0087-9
Publisher site
See Article on Publisher Site

Abstract

Virulent variants of Rice yellow mottle virus (genus Sobemovirus ) can emerge on the highly resistant rice cultivars Gigante and Bekarosaka. Non-synonymous mutations responsible for the breakdown of the recessive resistance gene rymv 1–2 were located in the VPg after determination of its termini in the polyprotein P2a. The secondary structure of this protein was predicted to include a central α-helix. The two major amino acids related to virulence are located on the same side of this helix. The 3D topology and the biochemical properties of virulence mutations both suggested a direct site-to-site interaction between RYMV VPg and rice eIF(iso)4G encoded by rymv 1.

Journal

Archives of VirologySpringer Journals

Published: Jun 1, 2008

References

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