virology division news : Obituary

virology division news : Obituary Arch Virol (2002) 147: 2473–2474 DOI 10.1007/s00705-002-0934-z Obituary In Memoriam Andreas Scheid (1941–2001) nveloped viruses enter cells by a mechanism of E membrane fusion. To this end, they have evolved fusion proteins that are often controlled by an activation process that involves proteolytic cleavage followed by a conformational change. Fusion events occurring in vesicular transport of uninfected cells follow similar principles. Some of the fundamental discoveries that led to these concepts were made by Andreas Scheid who died last year at the age of 60. Born in Munich, Andi Scheid spent most of his youth in Cologne where his father was head of the Department of Neurology of the university hospital. After attending medical school in Berlin, Zurich, and Cologne, Andi went in 1969 to the laboratory of Purnell Choppin at the Rockefeller University in New York as a postdoctoral fellow. Together with Purnell Choppin, he found in 1972 that both hemagglutinating and neuraminidase activities of the paramyxovirus SVS were associated with one of the two surface glycoproteins, which was therefore called HN protein. Analyzing Sendai virus, Scheid and Choppin reported shortly thereafter that the other paramyxovirus glycoprotein underwent proteolytic cleavage after trypsin treatment and that cleavage resulted in Archives of Virology Springer Journals

virology division news : Obituary

Archives of Virology , Volume 147 (12) – Nov 1, 2002

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