Vemurafenib Reactions 1680, p331 - 2 Dec 2017 Acantholytic dyskeratotic acanthoma: case report A 62-year-old woman developed acantholytic dyskeratotic acanthoma (ADA) following the therapy with vemurafenib. The woman was diagnosed with melanoma when she was 59 years old. She had undergone surgery, followed by nivolumab therapy. However, the disease progressed and advanced to systemic metastasis. Hence, to treat the multiple metastasis, she started receiving therapy with vemurafenib 960 mg/day [route not stated]. After one month of vemurafenib initiation, she developed a keratotic papule on her right shoulder. A skin biopsy of the papule was performed, which ruled out the possibility of squamous cell carcinoma. Histologically, the lesion demonstrated mild papillomatous acanthosis and hyperkeratosis. Acantholysis and dyskeratosis with corp ronds and grains were noted. Therefore, the papule was diagnosed as ADA that developed due to the vemurafenib therapy [outcome not stated]. Author comment: "In conclusion, we experienced a case of vemurafenib-induced ADA." Komori T, et al. Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. Journal of the European Academy of Dermatology and Venereology 31: e474-e475, No. 10, Oct 2017. Available from: URL: http:// - Japan 803284154 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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