Vemurafenib

Vemurafenib Reactions 1680, p333 - 2 Dec 2017 DRESS syndrome: case report A 51-year-old man developed DRESS syndrome during treatment with vemurafenib [route and dosage not stated]. The man with lentigo maligna melanoma of the ear was referred for lung, brain, liver and subcutaneous metastases at the age of 46 years. Five years later, he was initiated on vemurafenib treatment due to the progression of lung metastases. After 21 days of vemurafenib initiation, he presented with maculopapular exanthema and facial oedema. His laboratory tests showed eosinophilia with liver cytolysis and renal insufficiency. Consequently, he was diagnosed with DRESS syndrome, with a REGISCAR score of 6. As he was only receiving treatment with vemurafenib; his DRESS syndrome was considered to be caused by vemurafenib. As a result, the man’s vemurafenib was discontinued. He was initiated on corrective treatment with topical corticosteroids and prednisone. Within two weeks of vemurafenib discontinuation and start of corticosteroids, his laboratory tests and clinical condition improved. He was then started on nivolumab, followed by ipilimumab for the treatment of metastatic lentigo maligna melanoma. However, due to the progression of liver and a new bone metastasis, dabrafenib was started. He achieved partial remission during treatment with dabrafenib, without any recurrence of DRESS syndrome. Author comment: "We report the case of a patient with metastatic malignant melanoma in whom DRESS developed likely from vemurafenib." Pinard C, et al. Successful use of dabrafenib after the occurrence of drug rash with eosinophilia and systemic symptoms (DRESS) induced by vemurafenib. JAAD Case Reports 3: 532-533, No. 6, Nov 2017. Available from: URL: http:// doi.org/10.1016/j.jdcr.2017.06.027 - France 803285387 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Vemurafenib

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39264-1
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p333 - 2 Dec 2017 DRESS syndrome: case report A 51-year-old man developed DRESS syndrome during treatment with vemurafenib [route and dosage not stated]. The man with lentigo maligna melanoma of the ear was referred for lung, brain, liver and subcutaneous metastases at the age of 46 years. Five years later, he was initiated on vemurafenib treatment due to the progression of lung metastases. After 21 days of vemurafenib initiation, he presented with maculopapular exanthema and facial oedema. His laboratory tests showed eosinophilia with liver cytolysis and renal insufficiency. Consequently, he was diagnosed with DRESS syndrome, with a REGISCAR score of 6. As he was only receiving treatment with vemurafenib; his DRESS syndrome was considered to be caused by vemurafenib. As a result, the man’s vemurafenib was discontinued. He was initiated on corrective treatment with topical corticosteroids and prednisone. Within two weeks of vemurafenib discontinuation and start of corticosteroids, his laboratory tests and clinical condition improved. He was then started on nivolumab, followed by ipilimumab for the treatment of metastatic lentigo maligna melanoma. However, due to the progression of liver and a new bone metastasis, dabrafenib was started. He achieved partial remission during treatment with dabrafenib, without any recurrence of DRESS syndrome. Author comment: "We report the case of a patient with metastatic malignant melanoma in whom DRESS developed likely from vemurafenib." Pinard C, et al. Successful use of dabrafenib after the occurrence of drug rash with eosinophilia and systemic symptoms (DRESS) induced by vemurafenib. JAAD Case Reports 3: 532-533, No. 6, Nov 2017. Available from: URL: http:// doi.org/10.1016/j.jdcr.2017.06.027 - France 803285387 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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