Variability of the S gene of hepatitis B virus in southeastern China

Variability of the S gene of hepatitis B virus in southeastern China In a study of 315 HBV specimens obtained from southern China, 240 (76.9%) were assigned to genotype B, 72 (22.9%) were genotype C, two (0.6%) were genotype A and one (0.3%) was genotype D. Statistical analysis revealed that variables such as age, gender, HBV vaccination rate, hepatitis anamnesis rate, anti-HBs and HBeAg prevalence and virus load were insignificant between genotype B ( n = 240) and genotype C cases ( n = 72) ( P > 0.05). However, the frequency of amino acid (aa) substitutions in the major hydrophilic region (MHR; aa 99–169) and the putative HLA class I-restricted cytotoxic T lymphocyte (CTL) epitope region of the S gene, as well as the overlapping polymerase/RT region (aa 32–212), were significantly higher in genotype C group than genotype B ( P < 0.001). These results suggest that the higher variability within genotype C carriers may account for the pathogenic potential. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Variability of the S gene of hepatitis B virus in southeastern China

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Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-010-0786-x
Publisher site
See Article on Publisher Site

Abstract

In a study of 315 HBV specimens obtained from southern China, 240 (76.9%) were assigned to genotype B, 72 (22.9%) were genotype C, two (0.6%) were genotype A and one (0.3%) was genotype D. Statistical analysis revealed that variables such as age, gender, HBV vaccination rate, hepatitis anamnesis rate, anti-HBs and HBeAg prevalence and virus load were insignificant between genotype B ( n = 240) and genotype C cases ( n = 72) ( P > 0.05). However, the frequency of amino acid (aa) substitutions in the major hydrophilic region (MHR; aa 99–169) and the putative HLA class I-restricted cytotoxic T lymphocyte (CTL) epitope region of the S gene, as well as the overlapping polymerase/RT region (aa 32–212), were significantly higher in genotype C group than genotype B ( P < 0.001). These results suggest that the higher variability within genotype C carriers may account for the pathogenic potential.

Journal

Archives of VirologySpringer Journals

Published: Dec 1, 2010

References

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