Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention

Variability of platelet response to clopidogrel is not related to adverse cardiovascular events... Eur J Clin Pharmacol (2017) 73:1085–1094 DOI 10.1007/s00228-017-2271-x CLINICAL TRIAL Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention 1 1 2 Szymon Olędzki & Zdzisława Kornacewicz-Jach & Krzysztof Safranow & 1 3 4 Radosław Kiedrowicz & Barbara Gawrońska-Szklarz & Maria Jastrzębska & Jarosław Gorący Received: 3 March 2017 /Accepted: 22 May 2017 /Published online: 6 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract blood pressure, and platelet count comparing to that of other Background Antiplatelet response to clopidogrel and its influ- patients. LTPR was significantly associated with no history of ence upon the risk of cardiovascular adverse events among hypertension, younger age, lower platelet count, absence of patients with stable coronary artery disease undergoing percu- the CYP2C19*2 variant, and lower CRP plasma level. taneous coronary intervention (PCI) has not been investigated Overall, cardiac adverse events were noted in 14.23% pa- fully. tients. Survival analysis with the Cox proportional hazard Methods Two hundred eleven patients treated with aspirin model showed no influence of residual platelet reactivity dur- and clopidogrel were included in the study. Immediately be- ing clopidogrel therapy upon both ischemic and hemorrhagic fore http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention

Loading next page...
 
/lp/springer_journal/variability-of-platelet-response-to-clopidogrel-is-not-related-to-5eJsEeOSBA
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
D.O.I.
10.1007/s00228-017-2271-x
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial