Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention

Variability of platelet response to clopidogrel is not related to adverse cardiovascular events... Eur J Clin Pharmacol (2017) 73:1085–1094 DOI 10.1007/s00228-017-2271-x CLINICAL TRIAL Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention 1 1 2 Szymon Olędzki & Zdzisława Kornacewicz-Jach & Krzysztof Safranow & 1 3 4 Radosław Kiedrowicz & Barbara Gawrońska-Szklarz & Maria Jastrzębska & Jarosław Gorący Received: 3 March 2017 /Accepted: 22 May 2017 /Published online: 6 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract blood pressure, and platelet count comparing to that of other Background Antiplatelet response to clopidogrel and its influ- patients. LTPR was significantly associated with no history of ence upon the risk of cardiovascular adverse events among hypertension, younger age, lower platelet count, absence of patients with stable coronary artery disease undergoing percu- the CYP2C19*2 variant, and lower CRP plasma level. taneous coronary intervention (PCI) has not been investigated Overall, cardiac adverse events were noted in 14.23% pa- fully. tients. Survival analysis with the Cox proportional hazard Methods Two hundred eleven patients treated with aspirin model showed no influence of residual platelet reactivity dur- and clopidogrel were included in the study. Immediately be- ing clopidogrel therapy upon both ischemic and hemorrhagic fore http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
D.O.I.
10.1007/s00228-017-2271-x
Publisher site
See Article on Publisher Site

Abstract

Eur J Clin Pharmacol (2017) 73:1085–1094 DOI 10.1007/s00228-017-2271-x CLINICAL TRIAL Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention 1 1 2 Szymon Olędzki & Zdzisława Kornacewicz-Jach & Krzysztof Safranow & 1 3 4 Radosław Kiedrowicz & Barbara Gawrońska-Szklarz & Maria Jastrzębska & Jarosław Gorący Received: 3 March 2017 /Accepted: 22 May 2017 /Published online: 6 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract blood pressure, and platelet count comparing to that of other Background Antiplatelet response to clopidogrel and its influ- patients. LTPR was significantly associated with no history of ence upon the risk of cardiovascular adverse events among hypertension, younger age, lower platelet count, absence of patients with stable coronary artery disease undergoing percu- the CYP2C19*2 variant, and lower CRP plasma level. taneous coronary intervention (PCI) has not been investigated Overall, cardiac adverse events were noted in 14.23% pa- fully. tients. Survival analysis with the Cox proportional hazard Methods Two hundred eleven patients treated with aspirin model showed no influence of residual platelet reactivity dur- and clopidogrel were included in the study. Immediately be- ing clopidogrel therapy upon both ischemic and hemorrhagic fore

Journal

European Journal of Clinical PharmacologySpringer Journals

Published: Jun 6, 2017

References

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