Vancomycin-related partial necrosis of congenital hemangioma

Vancomycin-related partial necrosis of congenital hemangioma The term hemangioma refers to the common tumor of infancy that exhibits rapid postnatal growth and slow regression during childhood. Infantile hemangiomas are benign vascular neoplasms that develop from the dermal capillary network. Vancomycin is a bactericidal antibiotic agent commonly used in the treatment of infections caused by Gram-positive organisms. The most common adverse effect of intravenously administered vancomycin is “red man syndrome” (RMS), which is associated with the rapid infusion of large doses of vancomycin. This reaction is secondary to mast cell degranulation and is characterized by erythema, pruritus, flushing of the upper torso, and, in severe cases, angioedema and (rarely) cardiovascular complications. We present the case of a 3.5-month-old girl who developed partial hemangioma necrosis secondarily to RMS following intravenous administration of vancomycin for the treatment of Gram-positive bacteremia. Level of Evidence: Level V, prognostic / risk study. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Vancomycin-related partial necrosis of congenital hemangioma

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-015-1129-7
Publisher site
See Article on Publisher Site

Abstract

The term hemangioma refers to the common tumor of infancy that exhibits rapid postnatal growth and slow regression during childhood. Infantile hemangiomas are benign vascular neoplasms that develop from the dermal capillary network. Vancomycin is a bactericidal antibiotic agent commonly used in the treatment of infections caused by Gram-positive organisms. The most common adverse effect of intravenously administered vancomycin is “red man syndrome” (RMS), which is associated with the rapid infusion of large doses of vancomycin. This reaction is secondary to mast cell degranulation and is characterized by erythema, pruritus, flushing of the upper torso, and, in severe cases, angioedema and (rarely) cardiovascular complications. We present the case of a 3.5-month-old girl who developed partial hemangioma necrosis secondarily to RMS following intravenous administration of vancomycin for the treatment of Gram-positive bacteremia. Level of Evidence: Level V, prognostic / risk study.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Apr 1, 2016

References

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