Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events

Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and... Biometals (2018) 31:647–671 https://doi.org/10.1007/s10534-018-0117-3(0123456789().,-volV)(0123456789().,-volV) Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events . . Souvik Roy Sritama Banerjee Tania Chakraborty Received: 16 November 2017 / Accepted: 25 May 2018 / Published online: 31 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Flavonoid metal ion complexes have been to determine safe doses. 7,12-Dimethylbenz(a)an- deliberated in recent years and are considered as a new thracene (0.5 mg/100 g body weight) was used for class of medicinal agents with enhanced therapeutic induction of breast cancer in female Sprague–Dawley activity and low toxicity. Our study deals with rats via single tail vein injection. The histopatholog- chemotherapeutic effects of vanadium, when coordi- ical analysis after 24 weeks of carcinogenesis study nated with the flavonoid quercetin on a defined model depicted substantial repair of hyperplastic lesions. of chemically induced rat mammary carcinogenesis TUNEL assay showed an increase in apoptotic index in vivo and on human breast cancer cell line MCF-7 (0.14 ± 0.03; 0.15 ± 0.01) in vanadium–quercetin in vitro. The characterization of the complex was treated groups as compared to the carcinogen control achieved through UV–Visible, IR, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioMetals Springer Journals

Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events

Loading next page...
 
/lp/springer_journal/vanadium-quercetin-complex-attenuates-mammary-cancer-by-regulating-the-h1mWVzGex6
Publisher
Springer Netherlands
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Life Sciences; Biochemistry, general; Pharmacology/Toxicology; Microbiology; Cell Biology; Plant Physiology; Medicine/Public Health, general
ISSN
0966-0844
eISSN
1572-8773
D.O.I.
10.1007/s10534-018-0117-3
Publisher site
See Article on Publisher Site

Abstract

Biometals (2018) 31:647–671 https://doi.org/10.1007/s10534-018-0117-3(0123456789().,-volV)(0123456789().,-volV) Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events . . Souvik Roy Sritama Banerjee Tania Chakraborty Received: 16 November 2017 / Accepted: 25 May 2018 / Published online: 31 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Flavonoid metal ion complexes have been to determine safe doses. 7,12-Dimethylbenz(a)an- deliberated in recent years and are considered as a new thracene (0.5 mg/100 g body weight) was used for class of medicinal agents with enhanced therapeutic induction of breast cancer in female Sprague–Dawley activity and low toxicity. Our study deals with rats via single tail vein injection. The histopatholog- chemotherapeutic effects of vanadium, when coordi- ical analysis after 24 weeks of carcinogenesis study nated with the flavonoid quercetin on a defined model depicted substantial repair of hyperplastic lesions. of chemically induced rat mammary carcinogenesis TUNEL assay showed an increase in apoptotic index in vivo and on human breast cancer cell line MCF-7 (0.14 ± 0.03; 0.15 ± 0.01) in vanadium–quercetin in vitro. The characterization of the complex was treated groups as compared to the carcinogen control achieved through UV–Visible, IR,

Journal

BioMetalsSpringer Journals

Published: May 31, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off