Biometals (2018) 31:647–671 https://doi.org/10.1007/s10534-018-0117-3(0123456789().,-volV)(0123456789().,-volV) Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events . . Souvik Roy Sritama Banerjee Tania Chakraborty Received: 16 November 2017 / Accepted: 25 May 2018 / Published online: 31 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Flavonoid metal ion complexes have been to determine safe doses. 7,12-Dimethylbenz(a)an- deliberated in recent years and are considered as a new thracene (0.5 mg/100 g body weight) was used for class of medicinal agents with enhanced therapeutic induction of breast cancer in female Sprague–Dawley activity and low toxicity. Our study deals with rats via single tail vein injection. The histopatholog- chemotherapeutic effects of vanadium, when coordi- ical analysis after 24 weeks of carcinogenesis study nated with the ﬂavonoid quercetin on a deﬁned model depicted substantial repair of hyperplastic lesions. of chemically induced rat mammary carcinogenesis TUNEL assay showed an increase in apoptotic index in vivo and on human breast cancer cell line MCF-7 (0.14 ± 0.03; 0.15 ± 0.01) in vanadium–quercetin in vitro. The characterization of the complex was treated groups as compared to the carcinogen control achieved through UV–Visible, IR,
BioMetals – Springer Journals
Published: May 31, 2018
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