Valproic acid

Valproic acid Reactions 1680, p328 - 2 Dec 2017 Urine incontinence: 4 case reports In a case series, four children (two boys and two girls) aged 2.5 11 years were described, who developed urine incontinence during treatment with valproic acid [routes not stated]. All the four children started receiving treatment with valproic acid at a dose of 15 33 mg/kg/day for generalised tonic-clonic seizures (3 children) or symptomatic focal epilepsy (1 child). However, one of the four children immediately developed urinary incontinence, while the other three children developed urinary incontinence after receiving the therapy for ten days two months. Consequently, the treatment with valproic acid was discontinued in all the four children, and subsequent resolution of urinary incontinence was noted. Author comment: "All our cases scored a total of 6 points [as per Noranjo adverse drug probability scale]. This score is suggestive of a probable adverse drug reaction [of urine incontinence by valproic acid]." Sudan YS, et al. Urine Incontinence Induced by Valproic Acid. Indian Journal of Pediatrics 84: 867-868, No. 11, Nov 2017. Available from: URL: http:// doi.org/10.1007/s12098-017-2387-0 - India 803284082 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Valproic acid

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39259-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p328 - 2 Dec 2017 Urine incontinence: 4 case reports In a case series, four children (two boys and two girls) aged 2.5 11 years were described, who developed urine incontinence during treatment with valproic acid [routes not stated]. All the four children started receiving treatment with valproic acid at a dose of 15 33 mg/kg/day for generalised tonic-clonic seizures (3 children) or symptomatic focal epilepsy (1 child). However, one of the four children immediately developed urinary incontinence, while the other three children developed urinary incontinence after receiving the therapy for ten days two months. Consequently, the treatment with valproic acid was discontinued in all the four children, and subsequent resolution of urinary incontinence was noted. Author comment: "All our cases scored a total of 6 points [as per Noranjo adverse drug probability scale]. This score is suggestive of a probable adverse drug reaction [of urine incontinence by valproic acid]." Sudan YS, et al. Urine Incontinence Induced by Valproic Acid. Indian Journal of Pediatrics 84: 867-868, No. 11, Nov 2017. Available from: URL: http:// doi.org/10.1007/s12098-017-2387-0 - India 803284082 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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