Valproic-acid

Valproic-acid Reactions 1704, p363 - 2 Jun 2018 Aggravation of subtle psoriasis: case report A 7-year-old girl developed aggravation of subtle psoriasis following treatment with valproic acid for intractable seizures [route, dosage and time to reaction onset not stated]. The girl, who had seizure disorder presented with extensive papulos-squameous plaques on the skin and scalp. She had mild scaling for two years, which was managed with topical steroids. Four weeks prior to presentation, her treatment was switched from levetiracetam to valproic acid. At presentation, the clinical examination revealed generalised psoriasiform plaques predominantly on the feet, hand, scalp and severe nail dystrophy. A presumed diagnosis of aggravation of psoriasis was made. The girl started receiving methotrexate and intensive topical treatment. A moderate improvement was seen in the following 12 weeks. Her valproic acid treatment was switched to topiramate. In the following week (after valproic acid dose reduction), the skin condition improved. The valproic acid treatment was discontinued and she continued to receive methotrexate treatment but mild scaling of the scalp persists. Author comment: "Valproic acid is an antiepileptic drug frequently used in children. Even though the risk of aggravating psoriasis is known". "We present a child with a severe aggravation of a pre-existing psoriasis after starting treatment with valproic acid. " Schwieger-Briel A, et al. Severe aggravation of subtle psoriasis triggered by treatment with valproic acid. Pediatric Dermatology 35 (Suppl. 2): S28, Apr 2018. Available from: URL: http://doi.org/10.1111/pde.13555 [abstract] - Switzerland 803323420 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Valproic-acid

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-47006-8
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p363 - 2 Jun 2018 Aggravation of subtle psoriasis: case report A 7-year-old girl developed aggravation of subtle psoriasis following treatment with valproic acid for intractable seizures [route, dosage and time to reaction onset not stated]. The girl, who had seizure disorder presented with extensive papulos-squameous plaques on the skin and scalp. She had mild scaling for two years, which was managed with topical steroids. Four weeks prior to presentation, her treatment was switched from levetiracetam to valproic acid. At presentation, the clinical examination revealed generalised psoriasiform plaques predominantly on the feet, hand, scalp and severe nail dystrophy. A presumed diagnosis of aggravation of psoriasis was made. The girl started receiving methotrexate and intensive topical treatment. A moderate improvement was seen in the following 12 weeks. Her valproic acid treatment was switched to topiramate. In the following week (after valproic acid dose reduction), the skin condition improved. The valproic acid treatment was discontinued and she continued to receive methotrexate treatment but mild scaling of the scalp persists. Author comment: "Valproic acid is an antiepileptic drug frequently used in children. Even though the risk of aggravating psoriasis is known". "We present a child with a severe aggravation of a pre-existing psoriasis after starting treatment with valproic acid. " Schwieger-Briel A, et al. Severe aggravation of subtle psoriasis triggered by treatment with valproic acid. Pediatric Dermatology 35 (Suppl. 2): S28, Apr 2018. Available from: URL: http://doi.org/10.1111/pde.13555 [abstract] - Switzerland 803323420 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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