Valproate Reactions 1680, p327 - 2 Dec 2017 Generalised choreoathetosis: case report A 53-year-old woman developed generalised choreoathetosis during treatment with valproate. The woman had a history of mental retardation, epilepsy and a childhood meningitis. She presented with two breakthrough of generalised tonic clonic seizures. She started receiving valproate 900 mg/day [route not stated]. Few days later, she developed generalised involuntary movements and was lethargic [duration of treatment to reaction onset not stated]. Neurological test revealed continuous choreoathetotic movements involving mouth, lips, head, trunk, tongue and lower extremities with dystonic posturing of trunk and foot. Valproate blood level was within the normal limit. The woman’s valproate therapy was gradually discontinued, based on the temporal association between the onset of involuntary movements and valproate administration. As a result of this, there was a marked improvement within the first three days and then complete recovery was noted in a week. Author comment: ’’Our case is the first report of [valproate]-induced generalized choreoathetosis in a patient’’. Giordano A, et al. Valproate-Induced Generalized Choreoathetosis. Movement Disorders Clinical Practice 1: 271-272, No. 3, Sep 2014. Available from: URL: - Italy 803286076 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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