Reactions 1680, p327 - 2 Dec 2017
Generalised choreoathetosis: case report
A 53-year-old woman developed generalised
choreoathetosis during treatment with valproate.
The woman had a history of mental retardation, epilepsy and
a childhood meningitis. She presented with two breakthrough
of generalised tonic clonic seizures. She started receiving
valproate 900 mg/day [route not stated]. Few days later, she
developed generalised involuntary movements and was
lethargic [duration of treatment to reaction onset not stated].
Neurological test revealed continuous choreoathetotic
movements involving mouth, lips, head, trunk, tongue and
lower extremities with dystonic posturing of trunk and foot.
Valproate blood level was within the normal limit.
The woman’s valproate therapy was gradually discontinued,
based on the temporal association between the onset of
involuntary movements and valproate administration. As a
result of this, there was a marked improvement within the first
three days and then complete recovery was noted in a week.
Author comment: ’’Our case is the first report of
[valproate]-induced generalized choreoathetosis in a patient’’.
Giordano A, et al. Valproate-Induced Generalized Choreoathetosis. Movement
Disorders Clinical Practice 1: 271-272, No. 3, Sep 2014. Available from: URL:
http://doi.org/10.1002/mdc3.12069 - Italy
Reactions 2 Dec 2017 No. 16800114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved