Valinomycin as a Classical Anionophore: Mechanism and Ion Selectivity

Valinomycin as a Classical Anionophore: Mechanism and Ion Selectivity In the present study, we use theory and modeling to investigate K+ carrier valinomycin (Vln) as a classical anionophore. We discuss formation of the ion pair VlnK+, Cl− versus encapsulation of the anion into VlnCl− complex as two alternative mechanisms that could account for surprisingly high anionophoretic activity of the cyclic peptide (Riddell and Zhou in J Inorg Biochem 55:55–279, 1994), meanwhile constructing kinetic models to help distinguish between the two. The study is guided by the idea to create “valinomycin for anions” and in this respect the selectivity problem is at the heart, as synthetic anionophores are expected to have the same issues with the counterion translocation as Vln has. The study helps to understand what Vln really is and so what “valinomycin for anions” has to be. Furthermore, using recent examples, we explore how Vln has been utilized as a tool for research in the two different fields, with an aim to illustrate advantages and potential of basic scientific methods over supramolecular way, celebrating victory of science over commonsense. The Journal of Membrane Biology Springer Journals

Valinomycin as a Classical Anionophore: Mechanism and Ion Selectivity

Loading next page...
Springer US
Copyright © 2015 by Springer Science+Business Media New York
Life Sciences; Biochemistry, general; Human Physiology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial