Gastric Cancer (2017) 20:757–763 DOI 10.1007/s10120-017-0702-0 ORIGINAL ARTICLE Validation of the JCOG prognostic index in advanced gastric cancer using individual patient data from the SPIRITS and G-SOX trials 1 2 3 4 • • • • Daisuke Takahari Junki Mizusawa Wasaburo Koizumi Ichinosuke Hyodo Narikazu Boku Received: 25 December 2016 / Accepted: 5 February 2017 / Published online: 16 February 2017 The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2017 Abstract demonstrated highly signiﬁcant survival differences; the Background In a phase III study for advanced gastric hazard ratios (95% conﬁdence interval) were 1.71 cancer (AGC), the Japan Clinical Oncology Group (JCOG) (1.46–2.01) between the good (n = 338) and moderate 9912 trial, we previously identiﬁed the following four (n = 537) risk groups and 3.32 (2.47–4.46) between good prognostic factors—performance status C1, number of and poor (n = 61) risk groups. The median overall survival metastatic sites C2, no prior gastrectomy, and abnormal times of the good, moderate, and poor risk groups were serum alkaline phosphatase levels—and proposed a prog- 17.2, 12.0, and 7.8 months, respectively. nostic index (good risk with 0 or 1 factor, moderate risk Conclusions The JCOG prognostic index was externally with 2
Gastric Cancer – Springer Journals
Published: Feb 16, 2017
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