Validation of the 8th AJCC prognostic staging system for breast cancer in a population-based setting

Validation of the 8th AJCC prognostic staging system for breast cancer in a population-based setting Objectives To validate the newly proposed American Joint Committee on Cancer (AJCC) prognostic staging system for breast cancer. Methods Surveillance, epidemiology, and end results (SEER) database (2010–2014) was accessed. Cumulative incidence function was conducted (through assessment of sub-distribution hazard) according to both anatomical and prognostic stages. Likewise, Cox cause-specific hazard ratio with pairwise hazard ratio comparisons were also assessed for both anatomical and prognostic stages. Survival analyses according to both anatomical and prognostic staging systems were conducted through Kaplan–Meier analysis/log-rank testing. Results A total of 209,304 patients with non-metastatic breast cancer and upfront surgical treatment were included. Accord- ing to anatomical stages, pairwise Cox hazard ratio comparisons between different stages were significant ( P < 0.0001) except between stage IIIB and stage IIIC, while according to prognostic stages, all pairwise hazard ratio comparisons between different stages were significant ( P < 0.05). Sub-distribution hazard ratio (using breast cancer death as the primary failure endpoint and using other causes of death as competing causes of death) adjusted for age, race, and surgery was as follows: for the anatomical groups, it was 1.671 (95% CI 1.627–1.716; P < 0.0001) indicating increasing risk of death from breast cancer with increasing stage; however, for the prognostic groups it was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Research and Treatment Springer Journals

Validation of the 8th AJCC prognostic staging system for breast cancer in a population-based setting

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Oncology
ISSN
0167-6806
eISSN
1573-7217
D.O.I.
10.1007/s10549-017-4577-x
Publisher site
See Article on Publisher Site

Abstract

Objectives To validate the newly proposed American Joint Committee on Cancer (AJCC) prognostic staging system for breast cancer. Methods Surveillance, epidemiology, and end results (SEER) database (2010–2014) was accessed. Cumulative incidence function was conducted (through assessment of sub-distribution hazard) according to both anatomical and prognostic stages. Likewise, Cox cause-specific hazard ratio with pairwise hazard ratio comparisons were also assessed for both anatomical and prognostic stages. Survival analyses according to both anatomical and prognostic staging systems were conducted through Kaplan–Meier analysis/log-rank testing. Results A total of 209,304 patients with non-metastatic breast cancer and upfront surgical treatment were included. Accord- ing to anatomical stages, pairwise Cox hazard ratio comparisons between different stages were significant ( P < 0.0001) except between stage IIIB and stage IIIC, while according to prognostic stages, all pairwise hazard ratio comparisons between different stages were significant ( P < 0.05). Sub-distribution hazard ratio (using breast cancer death as the primary failure endpoint and using other causes of death as competing causes of death) adjusted for age, race, and surgery was as follows: for the anatomical groups, it was 1.671 (95% CI 1.627–1.716; P < 0.0001) indicating increasing risk of death from breast cancer with increasing stage; however, for the prognostic groups it was

Journal

Breast Cancer Research and TreatmentSpringer Journals

Published: Nov 15, 2017

References

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