Vaccines for the Prevention of Melioidosis and Glanders

Vaccines for the Prevention of Melioidosis and Glanders Curr Trop Med Rep (2017) 4:136–145 DOI 10.1007/s40475-017-0121-7 MELIOIDOSIS AND TROPICAL BACTERIOLOGY (A TORRES, SECTION EDITOR) 1 1 Monica M. Johnson & Kristy M. Ainslie Published online: 14 July 2017 Springer International Publishing AG 2017 Abstract mallei, the causative agent of glanders, are aerobic, gram-neg- Purpose of Review Burkholderia pseudomallei’sand ative, motile bacilli classified by the US Centers for Disease Burkholderia mallei’s high rate of infectivity, limited treat- Control and Prevention (CDC) as tier 1 select agents due to ment options, and potential use as biological warfare agents high virulence when inhaled and potential to cause large-scale underscore the need for development of effective vaccines illness if disseminated. Additionally, Burkholderia spp. against these bacteria. Research efforts focused on vaccines have resistance to a wide range of antibiotics, including against these bacteria are in preclinical stages, with no ap- penicillin [2, 3], which adds additional concern surround- proved formulations currently on the market. ing the bacteria. Research efforts over the last decade Recent Findings Several live attenuated and subunit vaccine have evaluated prophylactic and therapeutic treatment formulations have been evaluated in animal studies, with no options to combat these emerging infectious diseases; reports of significant long-term survival after lethal challenge. Current Tropical Medicine Reports Springer Journals

Vaccines for the Prevention of Melioidosis and Glanders

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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Medicine & Public Health; Tropical Medicine; Parasitology; Behavioral Sciences; Infectious Diseases
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