Arch Virol (2011) 156:1493–1494 DOI 10.1007/s00705-011-1058-0 BOOK REVIEW Vaccine design: Innovative Approaches and Novel Strategies Edited by Rino Rappuoli and Fabio Bagnoli (2011) Caister Academic Press, Norfolk, UK, 380 pages. ISBN :978-1-904455-74-5, Hardcover. $319 from Amazon.com Marc van Regenmortel Published online: 10 July 2011 Springer-Verlag 2011 This timely book reviews major advances in the ﬁeld of number of puriﬁed antigens, reverse vaccinology identiﬁes bacterial vaccines made possible by the increasing number hundreds of proteins as potential vaccine candidates and of whole genome sequences of bacterial pathogens deter- tests them for immunogenicity and protective efﬁcacy. mined in the last 15 years. Following an introductory Another advantage is that this strategy can be used with chapter by Ruth Arnon of the Weizmann Institute microorganisms that cannot be cultivated. describing various vaccine strategies used against micro- One chapter of the book is devoted to the ﬁrst successful bial diseases, Chapter 2 by Rino Rappuoli and his application of this new approach, namely the development colleagues from Novartis Vaccines in Siena, gives a of a vaccine against Meningococcus B (Men B), the comprehensive overview of a new approach known as pathogen that causes 50% of meningococcal meningitis reverse vaccinology. This approach, introduced ten
Archives of Virology – Springer Journals
Published: Aug 1, 2011
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