Pediatr Surg Int (2017) 33:961–970 DOI 10.1007/s00383-017-4115-2 ORIGINAL ARTICLE Utility of PAS and b-catenin staining in histological categorisation and prediction of prognosis of hepatoblastomas 1 1 2 1 • • • • Goutam Bera Ram Narayan Das Paromita Roy Ranajoy Ghosh 1 3 1 • • Nelofar Islam Prafulla Kumar Mishra Uttara Chatterjee Accepted: 18 April 2017 / Published online: 19 June 2017 Springer-Verlag GmbH Germany 2017 Abstract b-catenin and Ki-67 staining were done and their correla- Aims The aim of this study was to assess the usefulness of tion with histologic subtypes was assessed. Kaplan–Meier PAS, b-catenin and Ki-67 in categorising hepatoblastomas survival analysis was performed in relation to histology, (HBs) and their signiﬁcance in predicting prognosis. In PAS, b-catenin and Ki-67 staining characteristics. addition, we have also documented the various Result Diffuse nuclear staining of b-catenin was signiﬁ- chemotherapy induced histologic changes in HBs. cantly more common in embryonal predominant type Method In this retrospective observational study of 29 (p = 0.036), whereas strong PAS positivity was signiﬁ- cases of hepatoblastomas, 27 cases were considered for cantly associated with fetal predominant type (p = 0.002). statistical analysis, excluding two cases of diagnostic core But no signiﬁcant correlation
Pediatric Surgery International – Springer Journals
Published: Jun 19, 2017
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