Using the Symmetry Analysis Design to Screen for Adverse Effects of Non-vitamin K Antagonist Oral Anticoagulants

Using the Symmetry Analysis Design to Screen for Adverse Effects of Non-vitamin K Antagonist Oral... Drug Saf (2018) 41:685–695 https://doi.org/10.1007/s40264-018-0650-6 ORIGINAL RESEARCH ARTICLE Using the Symmetry Analysis Design to Screen for Adverse Effects of Non-vitamin K Antagonist Oral Anticoagulants 1 1 1 1 • • • Maja Hellfritzsch Lotte Rasmussen Jesper Hallas Anton Pottega˚rd Published online: 1 March 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract use of anticoagulants was associated with strengthening of Introduction Knowledge on adverse effects (AEs) related all ‘‘NOAC-adverse effect’’ associations. Conversely, use to non-vitamin K antagonist oral anticoagulants (NOACs) of low-dose NOAC and apixaban led to attenuation of most in real-world populations is sparse. associations. Objective Our objective was to identify signals of potential Conclusion Through a symmetry analysis-based hypothe- AEs in patients with atrial fibrillation (AF) initiating sis-free screening of large-scale healthcare databases, we NOAC treatment using a hypothesis-free screening were able to confirm well-established AEs of NOAC approach. therapy in clinical practice as well as potential AEs that Methods Using the nationwide Danish registries, we deserve further investigation. identified patients with AF initiating dabigatran, rivaroxa- ban, or apixaban between 2011 and 2015 (n = 50,627). Applying a symmetry analysis design, we screened for AEs Key Points of NOAC, as reflected by new drug treatments, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Safety Springer Journals

Using the Symmetry Analysis Design to Screen for Adverse Effects of Non-vitamin K Antagonist Oral Anticoagulants

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-5916
eISSN
1179-1942
D.O.I.
10.1007/s40264-018-0650-6
Publisher site
See Article on Publisher Site

Abstract

Drug Saf (2018) 41:685–695 https://doi.org/10.1007/s40264-018-0650-6 ORIGINAL RESEARCH ARTICLE Using the Symmetry Analysis Design to Screen for Adverse Effects of Non-vitamin K Antagonist Oral Anticoagulants 1 1 1 1 • • • Maja Hellfritzsch Lotte Rasmussen Jesper Hallas Anton Pottega˚rd Published online: 1 March 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract use of anticoagulants was associated with strengthening of Introduction Knowledge on adverse effects (AEs) related all ‘‘NOAC-adverse effect’’ associations. Conversely, use to non-vitamin K antagonist oral anticoagulants (NOACs) of low-dose NOAC and apixaban led to attenuation of most in real-world populations is sparse. associations. Objective Our objective was to identify signals of potential Conclusion Through a symmetry analysis-based hypothe- AEs in patients with atrial fibrillation (AF) initiating sis-free screening of large-scale healthcare databases, we NOAC treatment using a hypothesis-free screening were able to confirm well-established AEs of NOAC approach. therapy in clinical practice as well as potential AEs that Methods Using the nationwide Danish registries, we deserve further investigation. identified patients with AF initiating dabigatran, rivaroxa- ban, or apixaban between 2011 and 2015 (n = 50,627). Applying a symmetry analysis design, we screened for AEs Key Points of NOAC, as reflected by new drug treatments,

Journal

Drug SafetySpringer Journals

Published: Mar 1, 2018

References

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