Drug Saf (2018) 41:685–695 https://doi.org/10.1007/s40264-018-0650-6 ORIGINAL RESEARCH ARTICLE Using the Symmetry Analysis Design to Screen for Adverse Effects of Non-vitamin K Antagonist Oral Anticoagulants 1 1 1 1 • • • Maja Hellfritzsch Lotte Rasmussen Jesper Hallas Anton Pottega˚rd Published online: 1 March 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract use of anticoagulants was associated with strengthening of Introduction Knowledge on adverse effects (AEs) related all ‘‘NOAC-adverse effect’’ associations. Conversely, use to non-vitamin K antagonist oral anticoagulants (NOACs) of low-dose NOAC and apixaban led to attenuation of most in real-world populations is sparse. associations. Objective Our objective was to identify signals of potential Conclusion Through a symmetry analysis-based hypothe- AEs in patients with atrial ﬁbrillation (AF) initiating sis-free screening of large-scale healthcare databases, we NOAC treatment using a hypothesis-free screening were able to conﬁrm well-established AEs of NOAC approach. therapy in clinical practice as well as potential AEs that Methods Using the nationwide Danish registries, we deserve further investigation. identiﬁed patients with AF initiating dabigatran, rivaroxa- ban, or apixaban between 2011 and 2015 (n = 50,627). Applying a symmetry analysis design, we screened for AEs Key Points of NOAC, as reﬂected by new drug treatments,
Drug Safety – Springer Journals
Published: Mar 1, 2018
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