A collection of spontaneous “Roman’s mutants” (1654 mutants) for early genes of purine biosynthesis PUR1–PUR5 was obtained from 16 parental ade1 (pur6) and ade2(pur7) strains of the methylotrophic yeast Pichia methanolica. Two genes, bifunctiional ADE7,4(PUR2,5) and ADE5(PUR4), were identified earlier. For identification of the two remaining early genes (ADE3 and ADE8), a novel approach was used: a comparison of spectra of spontaneous Roman’s mutants and relative sizes of genes (with regard to the length of polypeptides in amino acid residues).
Russian Journal of Genetics – Springer Journals
Published: Oct 11, 2009
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