Use of site-specific DNA endonucleases in genome-wide studies of human DNA

Use of site-specific DNA endonucleases in genome-wide studies of human DNA During the last decades, site-specific DNA endonucleases have served as a key instrument to study primary structure of DNA and genetic engineering. Here, we describe examples of these enzyme uses in genome-wide analysis of human DNA including restriction endonucleases involvement during sample preparation for sequencing using NGS devices, as well as visualization of cleavage of DNA repeats by endonucleases. The first studies on application of DNA endonucleases in the rapidly developing area of epigenetic analysis of genomes, which is facilitated by the recent discovery of a new class of enzymes, 5-methylcytosinedependent site-specific DNA endonucleases, are of special interest. Russian Journal of Genetics Springer Journals

Use of site-specific DNA endonucleases in genome-wide studies of human DNA

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Pleiades Publishing
Copyright © 2017 by Pleiades Publishing, Inc.
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
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