Use of Knock-out Mouse Models for the Study of Renal Ion Channels

Use of Knock-out Mouse Models for the Study of Renal Ion Channels J. Membrane Biol. 198, 113–124 (2004) DOI: 10.1007/s00232-004-0665-z Topical Review H. Barrie` re, M. Tauc, P. Poujeol UMR CNRS 6548, Universite´ de Nice-Sophia Antipolis, 06108 Nice Cedex 2, France Received: 12December 2003 Introduction channels in proximal tubule cells from task2–/– mice (Barriere et al., 2003a). In this case, using this mouse, The development of transgenic mice bearing null the role of TASK2both in the RVD process and in mutations of different genes encoding channel pro- bicarbonate reabsorption has been demonstrated teins has opened a large field of investigation, which (Barriere et al., 2003a; Warth et al., 2002). allows a better understanding of the physiological Using kcne1 –/– mice has revealed a role for the mechanisms controlled by these proteins. For in- KCNE1 subunit in the control of swelling-activated ) + stance, a number of ion channels have been identified Cl and K currents (Barriere et al., 2003c). Unfor- in the mammalian kidney, but their physiological role tunately, the mechanism by which KCNE1 modu- remains largely unknown. Therefore, it was interest- lates these currents remains unknown. The lack of ing to use knock-out (KO) mice for these channels to these currents might explain the origin of the en- + ) The Journal of Membrane Biology Springer Journals

Use of Knock-out Mouse Models for the Study of Renal Ion Channels

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Copyright © 2004 by Springer-Verlag
Life Sciences; Human Physiology; Biochemistry, general
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