Use of fundamental properties of embryonic objects for studying potential environmental effects of technogenic impacts

Use of fundamental properties of embryonic objects for studying potential environmental effects... This article analyzes the problems of biosafety in terms of individual development patterns. Previously, the key role of epigenetic free radical processes in normal embryonic development of lower vertebrates in the formation of the competence and determination of embryonic primordia has been demonstrated, and a significant increase in the intensity of free radical process before every qualitative change in homeostatic mechanisms in developing organisms was found: in induction systems, before hatching of the embryo from the shells, and in preparation for metamorphosis. Thus, the activation of free radical processes in embryonic primordia corresponds to instability and characterizes the “critical periods of development” and increased sensitivity of the embryo to environmental impacts. Patented methods and a test system that allows detecting early biological effects of weak environmental impacts and predicting their environmental risk are presented. Possible mechanisms of significant biological effects of weak radiation and chemical impacts on the developing organism are discussed. The necessity of including embryonic objects in the protocol of testing the biosafety of technological developments is substantiated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Use of fundamental properties of embryonic objects for studying potential environmental effects of technogenic impacts

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Publisher
Pleiades Publishing
Copyright
Copyright © 2017 by Pleiades Publishing, Inc.
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360417010088
Publisher site
See Article on Publisher Site

Abstract

This article analyzes the problems of biosafety in terms of individual development patterns. Previously, the key role of epigenetic free radical processes in normal embryonic development of lower vertebrates in the formation of the competence and determination of embryonic primordia has been demonstrated, and a significant increase in the intensity of free radical process before every qualitative change in homeostatic mechanisms in developing organisms was found: in induction systems, before hatching of the embryo from the shells, and in preparation for metamorphosis. Thus, the activation of free radical processes in embryonic primordia corresponds to instability and characterizes the “critical periods of development” and increased sensitivity of the embryo to environmental impacts. Patented methods and a test system that allows detecting early biological effects of weak environmental impacts and predicting their environmental risk are presented. Possible mechanisms of significant biological effects of weak radiation and chemical impacts on the developing organism are discussed. The necessity of including embryonic objects in the protocol of testing the biosafety of technological developments is substantiated.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Feb 23, 2017

References

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