Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability

Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to... Summary The National Bone Health Alliance (NBHA) preparations were made based on review of available publica- recommends standardized sample handling and patient tions and pragmatic considerations to reduce pre-analytical preparation for C-terminal telopeptide of type I collagen variability. Controllable and un-controllable patient-related (CTX-I) and N-terminal propeptide of type I procollagen factors were reviewed to facilitate interpretation and sample (PINP) measurements to reduce pre-analytical variability. collection. Results Samples for CTX-I must be collected consistently Controllable and uncontrollable patient-related factors are reviewed to facilitate interpretation and minimize pre-an- in the morning hours in the fasted state. EDTA plasma is preferred for CTX-I for its greater sample stability. Sample alytical variability. Introduction The IOF and the International Federation of collection conditions for PINP are less critical as PINP has Clinical Chemistry (IFCC) Bone Marker Standards minimal circadian variability and is not affected by food Working Group have identified PINP and CTX-I in blood intake. Sample stability limits should be observed. The to be the reference markers of bone turnover for the frac- uncontrollable aspects (age, sex, pregnancy, immobility, ture risk prediction and monitoring of osteoporosis treat- recent fracture, co-morbidities, anti-osteoporotic drugs, ment. Although used in clinical research for many years, other medications) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Osteoporosis International Springer Journals

Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability

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Publisher
Springer London
Copyright
Copyright © 2017 by International Osteoporosis Foundation and National Osteoporosis Foundation
Subject
Medicine & Public Health; Orthopedics; Endocrinology; Rheumatology
ISSN
0937-941X
eISSN
1433-2965
D.O.I.
10.1007/s00198-017-4082-4
Publisher site
See Article on Publisher Site

Abstract

Summary The National Bone Health Alliance (NBHA) preparations were made based on review of available publica- recommends standardized sample handling and patient tions and pragmatic considerations to reduce pre-analytical preparation for C-terminal telopeptide of type I collagen variability. Controllable and un-controllable patient-related (CTX-I) and N-terminal propeptide of type I procollagen factors were reviewed to facilitate interpretation and sample (PINP) measurements to reduce pre-analytical variability. collection. Results Samples for CTX-I must be collected consistently Controllable and uncontrollable patient-related factors are reviewed to facilitate interpretation and minimize pre-an- in the morning hours in the fasted state. EDTA plasma is preferred for CTX-I for its greater sample stability. Sample alytical variability. Introduction The IOF and the International Federation of collection conditions for PINP are less critical as PINP has Clinical Chemistry (IFCC) Bone Marker Standards minimal circadian variability and is not affected by food Working Group have identified PINP and CTX-I in blood intake. Sample stability limits should be observed. The to be the reference markers of bone turnover for the frac- uncontrollable aspects (age, sex, pregnancy, immobility, ture risk prediction and monitoring of osteoporosis treat- recent fracture, co-morbidities, anti-osteoporotic drugs, ment. Although used in clinical research for many years, other medications)

Journal

Osteoporosis InternationalSpringer Journals

Published: Jun 19, 2017

References

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