J Cancer Res Clin Oncol (2017) 143:1757–1769 DOI 10.1007/s00432-017-2433-3 ORIGINAL ARTICLE – CANCER RESEARCH Urinary transcript quantitation of CK20 and IGF2 for the non‑invasive bladder cancer detection 1 1 2 2 2 Karsten Salomo · Doreen Huebner · Manja U. Boehme · Alexander Herr · Werner Brabetz · 1 3 3 4 4 Ulrike Heberling · Oliver W. Hakenberg · Daniela Jahn · Marc‑Oliver Grimm · Daniel Steinbach · 5 1 1 1 Marcus Horstmann · Michael Froehner · Manfred P. Wirth · Susanne Fuessel Received: 24 February 2017 / Accepted: 24 April 2017 / Published online: 8 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract 84.0%) were similar to that of VUC. The sensitivity of Purpose Cytokeratin 20 (CK20) and insulin-like growth VUC in combination with CK20 and IGF2 was consider- factor 2 (IGF2) were previously proposed to be elevated in ably increased (SN : 94.6; SN : 93.2%) while specificity TC VC clinical samples from patients with bladder cancer (BCa). was reduced (SP : 72.0; SP : 82.0%) compared to VUC TC VC A two cohort design validation study was used to assess the alone in the test and validation cohort. relevance for BCa detection by transcript
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: May 8, 2017
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