Diabetologia (2017) 60:1782–1790 DOI 10.1007/s00125-017-4328-x ARTICLE Urinary liver-type fatty acid binding protein is an independent predictor of stroke and mortality in individuals with type 1 diabetes 1,2,3,4 2,3,4 2,3,4 Nicolae M. Panduru & Carol Forsblom & Markku Saraheimo & 2,3,4 2,3,4 2,3,4 2,3,4,5 Lena M. Thorn & Daniel Gordin & Nina Elonen & Valma Harjusalo & 6 6,7 2,3,4,8 Angelika Bierhaus & Per M. Humpert & Per-Henrik Groop & on behalf of the FinnDiane Study Group Received: 6 March 2017 /Accepted: 9 May 2017 /Published online: 10 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract 1.49]) and after further adjustment for eGFR (HR 1.28 [95% Aims/hypothesis In type 1 diabetes, cardiovascular disease CI 1.14, 1.44]) or AER (HR 1.24 [95% CI 1.06, 1.44]). In (CVD) and diabetic nephropathy progress in parallel, thereby addition, it predicted mortality independently of traditional potentiating the risk of premature death during their develop- risk factors (HR 1.34 [95% CI 1.24, 1.45]), and after adjust- ment. Since urinary liver-type fatty acid binding protein (L- ment for eGFR (HR 1.29 [95% CI 1.18, 1.39]) or AER (HR FABP) predicts the progression of diabetic nephropathy, the 1.22 [95% CI 1.09, 1.36]). Urinary L-FABP was as good a aim
Diabetologia – Springer Journals
Published: Jun 10, 2017
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